Screen LibraryNMR of biomolecules : towards mechanistic systems biology /
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| Corporate Authors: | |
|---|---|
| Group Author: | ; ; |
| Published: |
Wiley-VCH,
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| Publisher Address: | Weinheim, Germany : |
| Publication Dates: |
[2012] ©2012 |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/9783527644506 |
| Carrier Form: | 1 onine resource (xxxviii, 612 pages) : illustrations |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9783527644506 (electronic bk.) 3527644504 (electronic bk.) 9783527644520 (electronic bk.) 3527644520 (electronic bk.) 3527644512 (ePub) 9783527644513 (ePub) 3527644539 (Mobi) 9783527644537 (Mobi) 9781283644037 (MyiLibrary) 1283644037 (MyiLibrary) |
| Index Number: | QP519 |
| CLC: | Q511 |
| Contents: |
Introduction. NMR and its Place in Mechanistic Systems Biology / Structure of Biomolecules: Fundamentals / What Can be Learned about the Structure and Dynamics of Biomolecules from NMR / Role of NMR in the Study of the Structure and Dynamics of Biomolecules. Determination of Protein Structure and Dynamics / DNA / RNA / Intrinsically Disordered Proteins / Paramagnetic Molecules / Role of NMR in the Study of the Structure and Dynamics of Biomolecular Interactions. NMR Methodologies for the Analysis of Protein₆Protein Interactions / Protein₆Paramagnetic Protein Interactions / Protein₆RNA Interactions / Protein₆DNA Interactions / NMR in Drug Discovery. High-Throughput Screening and Fragment-Based Design: General Considerations for Lead Discovery and Optimization / Ligand-Observed NMR in Fragment-Based Approaches / Interactions of Metallodrugs with DNA / RNA as a Drug Target / Fluorine NMR Spectroscopy for Biochemical Screening in Drug Discovery / NMR of Peptides / Solid-State NMR. Biomolecular Solid-State NMR/Basics / Protein Dynamics in the Solid State / Microcrystalline Proteins ₆ An Ideal Benchmark for Methodology Development / Structural Studies of Protein Fibrils by Solid-State NMR / Solid-State NMR on Membrane Proteins: Methods and Applications / Frontiers in NMR Spectroscopy. Dynamic Nuclear Polarization / C Direct Detection NMR / Speeding up Multidimensional NMR Data Acquisition / Metabolomics / In-Cell Protein NMR Spectroscopy / Structural Investigation of Cell-Free Expressed Membrane Proteins / Computational Aspects. Grid Computing / Protein₆Protein Docking with HADDOCK / Automated Protein Structure Determination Methods / NMR Structure Determination of Protein₆Ligand Complexes / Small Angle X-Ray Scattering/Small Angle Neutron Scattering as Methods Complementary to NMR / |