Screen LibraryHuman Retrotransposons in Health and Disease /
This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80 s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-med...
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| Published: |
Springer International Publishing : Imprint: Springer,
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| Publisher Address: | Cham : |
| Publication Dates: | 2017. |
| Literature type: | eBook |
| Language: | English |
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| Online Access: |
http://dx.doi.org/10.1007/978-3-319-48344-3 |
| Summary: |
This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80 s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many can |
| Carrier Form: | 1 online resource (X, 330 pages) : illustrations |
| ISBN: | 9783319483443 |
| Index Number: | RB155 |
| CLC: | Q987 |
| Contents: | Retrotransposons and the Mammalian Germline -- L1 regulation in Mouse and Human Germ Cells -- Retrotransposon Contribution to Genomic Plasticity -- The Mobilization of Processed Transcripts in Germline and Somatic Tissues -- Neuronal Genome Plasticity: Retrotransposons, Environment and Disease -- Activity of Retrotransposons in Stem Cells and Differentiated Cells -- Environment, Cellular Signaling and L1 activity -- Retrotransposon-derived Regulatory Regions and Transcripts in Stemness -- Roles of Endogenous Retrovirus-encoded Syncytins in Human Placentation -- Alu-Alu Recombinations in Gene |