Screen LibraryPrimary immunodeficiency disorders : a historic and scientific perspective /
Primary Immunodeficiency Disorders: A Historic and Scientific Perspective provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can m...
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| Corporate Authors: | |
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| Group Author: | ; |
| Published: |
Academic Press,
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| Publisher Address: | Oxford, England ; Waltham, Massachusetts : |
| Publication Dates: |
2014. ©2014 |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
http://www.sciencedirect.com/science/book/9780124071797 |
| Summary: |
Primary Immunodeficiency Disorders: A Historic and Scientific Perspective provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can miss important points about a disease, or miss out on how to approach new diseases. This historical knowledge of research can assist greatly by showing how it was done in the past, demonstrating the successes and failures, so that it can be done better in the future. This book provides an unders. |
| Carrier Form: | 1 online resource (377 pages) : illustrations |
| Bibliography: | Includes bibliographical references at the end of each chapters and index. |
| ISBN: |
9780124115545 0124115543 |
| Index Number: | RC600 |
| CLC: | R593.2 |
| Contents: |
Cover; Title Page; Copyright Page; Contents; Contributors; Foreword; The Giants of Our Field; The right time; The right place; Introduction; Chapter 1 -- Immunity: From Serendipitous Observations to Science-Based Specialty; Serendipitous Observations; A Cell Derives From a Cell, a Microorganism from a Microbe; Serum therapy, active Immunization and the concept of antibodies; Epicrisis; References; Chapter 2 -- Discovery of the T- and B-Cell Compartments; Introduction; Discovery of the importance of the thymus in immune system development; En route to Bob Good's research group in Minnesota. The atmosphere in Bob Good's laboratoryConnecting Studies in Chicks and Immunodeficiency Diseases; The key experiments in irradiated birds; The initial T- and B-cell model and its clinical implications; Basic questions posed by the separate T- and B-lineage model; The long search for the mammalian bursa-equivalent; The identification of B-lineage progenitors; An ancient blueprint for the T- and B-cell lineages; Acknowledgments; References; Chapter 3 -- Evolution of the Definition of Primary Immunodeficiencies; Introduction. The birth of classical PIDs, illustrated by the discovery of X-linked agammaglobulinemiaThe concept of PIDs with narrow phenotype, illustrated by X-linked lymphoproliferative disease; The development of PIDs with narrow phenotype, illustrated by Mendelian susceptibility to mycobacterial disease; PIDs with narrow phenotypes underlying common infections, illustrated by herpes simplex virus encephalitis of childhood; Conclusions and perspectives; Acknowledgments; References; Chapter 4 -- From Immunodeficiency to Autoimmunity. A Historical Journey into Recognition of Immunodeficiency and AutoimmunityAutoimmunity: An Often Neglected Feature of Immune Deficiency; Omenn Syndrome: Inflammation and Autoimmunity in Immune Deficiency; Expanding the Spectrum of Autoimmunity in RAG Deficiency; The Lesson Learned: When Combined Immunodeficiency and Autoimmunity go Hand-In-Hand; References; Chapter 5 -- Immunological Tests -- from the Microscope to Whole Genome Analysis; Introduction; History of the Evaluation of Humoral Immunity; History of the Evaluation of Cellular (T-cell) Immunity. History of the Evaluation of the IL12/23-interferon-g circuitHistory of the Evaluation of NK-cell defects; History of the Evaluation of Toll-like receptor defects; History of the Evaluation of Neutrophil Immunity; History of the Evaluation of the Complement System; Conclusion; Acknowledgment; References; Chapter 6 -- Primary Immunodeficiency in the Developing Countries; Introduction; History of Primary Immunodeficiency in Africa; Early Initiatives by Individual Visionaries; Establishment of Centers Specializing in PID; Efforts to Organize: The Foundation of ASID; PID Management in Africa. |