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Adenoviral vectors for gene therapy /

Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use...

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Bibliographic Details
Corporate Authors: Elsevier Science & Technology
Group Author: Curiel, David; Douglas, Joanne T
Published: Academic Press,
Publisher Address: Amsterdam ; Boston :
Publication Dates: 2002.
Literature type: eBook
Language: English
Subjects:
Gene therapy
Adenoviruses
Genetic Therapy > methods
Adenoviridae
Genetic vectors > Therapeutic use
The rapie ge nique
Ade novirus
HEALTH & FITNESS > Diseases > Genetic
MEDICAL > Genetics
Adenovi rus
Genes virais
Vi rus de dna
Electronic books
Online Access: http://www.sciencedirect.com/science/book/9780121995041
Summary: Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors.
Carrier Form: 1 online resource (xxviii, 677 pages) : illustrations
Bibliography: Includes bibliographical references.
ISBN: 9781435632004
1435632001
Index Number: RB155
CLC: R596.05
Contents: Adenovirus Structure -- Biology of Adenovirus Cell Entry -- Adenovirus Replication -- Adenoviral Vector Construction I: Mammalian Systems -- Adenoviral Vector Construction II: Bacterial Systems -- Propagation of Adenoviral Vectors: Use of PER. C6 Cells -- Purification of Adenovirus -- Targeted Adenoviral Vectors I: Transductional Targeting -- Targeted Adenoviral Vectors II: Transcriptional Targeting -- Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer -- Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer

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