Screen LibraryProtein kinase C in cancer signaling and therapy
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| Corporate Authors: | |
|---|---|
| Group Author: | |
| Published: |
Springer,
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| Publisher Address: | New York |
| Publication Dates: | c2010. |
| Literature type: | Book |
| Language: | English |
| Series: |
Current cancer research |
| Subjects: | |
| Online Access: |
http://dx.doi.org/10.1007/978-1-60761-543-9 |
| Carrier Form: | xiv, 494 p.: ill. ; 24 cm. |
| ISBN: |
9781607615439 (electr. bk.) 1607615436 9781607615422 1607615428 |
| Index Number: | R730 |
| CLC: |
R730.53 Q556 |
| Contents: |
Includes index. Includes bibliographical references and index. Protein kinase C in cancer signaling and therapy: introduction and historical perspective -- Regulation of conventional and novel protein kinase C isozymes by phosphorylation and lipids -- Phorbol esters and diacylglycerol: the PKC activators -- Diacylglycerol signaling: the C1 domain, generation of DAG and termination of signals -- Regulation of PKC by protein-protein interaction in cancer -- Introduction: PKC isozymes in the control of cell function -- Regulation and function of protein kinase C signaling -- PKC and control of the cell cycle -- PKC and the control of apoptosis -- Atypical PKC's, NF-kB and inflammation -- Introduction: PKC and cancer -- Protein kinase C, p53, and DNA damage -- PKCs as mediators of the hedgehog and Wnt signaling pathways -- PKC-PKD interplay in cancer -- Transgenic mouse models to investigate functional specificity of protein kinase C isoforms in the developoment of squamous cell carcinoma, a nonmelanoma human skin cancer -- PKC isozymes and skin cancer -- PKC and breast cancer -- PKC and prostate cancer -- Protein kinase C and lung cancer -- Introduction [PKC isozymes as targets for cancer therapy] -- PKC and resistance to chemotherapeutic agents -- PKCd as a target for chemotherapeutic drugs -- Atypical PKCs as targets for cancer therapy. |