Reset Filters
Author: 孟繁华
Branch:
Filter Related Topics: 中国文学

Cover is for reference only

Nitrosoureas : current status and new developments /

Nitrosoureas: Current Status and New Developments covers the preclinical and clinical status of nitrosoureas. The book presents preclinical studies on the development of the nitrosoureas; combination chemotherapy with nitrosoureas plus other anticancer drugs against animal tumors; EORTC studies with...

Full description

Saved in:
Bibliographic Details
Corporate Authors: Elsevier Science & Technology.
Group Author: Prestayko, Archie W.
Published: Academic Press,
Publisher Address: New York :
Publication Dates: 1981.
Literature type: eBook
Language: English
Subjects:
Nitrosoureas > Therapeutic use > Congresses.
Cancer > Chemotherapy > Congresses.
Nitrosoureas > Testing > Congresses.
Nitrosoureas > Metabolism > Congresses.
Drug Evaluation, Preclinical.
Drug Evaluation.
Neoplasms > drug therapy.
Nitrosourea Compounds > pharmacology.
Nitrosourea Compounds > therapeutic use.
Nitroso-ure es > Emploi en the rapeutique > Congre s.
Cancer > Chimiothe rapie > Congre s.
Nitroso-ure es > Essais > Congre s.
Nitroso-ure es > Me tabolisme > Congre s.
HEALTH & FITNESS > General. > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Electronic books.
Online Access: http://www.sciencedirect.com/science/book/9780125650601
Summary: Nitrosoureas: Current Status and New Developments covers the preclinical and clinical status of nitrosoureas. The book presents preclinical studies on the development of the nitrosoureas; combination chemotherapy with nitrosoureas plus other anticancer drugs against animal tumors; EORTC studies with novel nitrosoureas; and chemical decomposition of chloroethylnitrosoureas. The text also includes preclinical studies on the metabolism of nitrosoureas; DNA crosslinking and the origin of sensitivity to chloroethylnitrosoureas; modification of DNA and RNA bases; and carbamoylating activity of nitr.
Carrier Form: 1 online resource (xix, 416 pages) : illustrations
Bibliography: Includes bibliographical references.
ISBN: 9781483219448
1483219445
Index Number: RC271
CLC: R979.1
Contents: Front Cover; Nitrosoureas: Current Status and New Developments; Copyright Page; Table of Contents; Contributors; Preface; Section I: PRECLINICAL STUDIES; Chapter 1. The Development of the Nitrosoureas: A Study in Congener Synthesis; I. N-Nitroso Function; II. Chloroethyl Moiety; III. Antitumor Activity in Animal Tumors; IV. Conclusion; References; Chapter 2. Combination Chemotherapy with Nitrosoureas plus Other Anticancer Drugs against Animal Tumors; I. Introduction; II. Biologic Activity of Nitrosoureas in Combination with Other Anticancer Drugs; III. Discussion; IV. Summary; References.
Chapter 3. EORTC Studies with Novel NitrosoureasI. Introduction; II. The Chemotherapeutic Activity of HECNU and Other NU Derivatives; III. Selecting among NU Analogs; IV. Conclusion; ACKNOWLEDGMENT; References; Chapter 4. Chemical Decomposition of Chloroethylnitrosoureas; I. Introduction; II. Decomposition of Nitrosoureas; III. Decomposition of Other ""Nitroso"" Compounds; IV. Conclusion; References; Chapter 5. Metabolism of Nitrosoureas; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; V. Conclusions; VI. References.
Chapter 6. DNA Crosslinking and the Origin of Sensitivity to ChloroethylnitrosoureasI. Introduction; II. Materials and Methods; III. Results; IV. Discussion; References; Chapter 7. Modification of DNA and RNA Bases; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; References; Chapter 8. Carbamoylating Activity of Nitrosoureas; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; ACKNOWLEDGMENT; References; Chapter 9. Chromatin and Associated Nuclear Components as Potential Drug Targets; I. Introduction; II. Results.
III. Conclusion and PerspectivesReferences; Chapter 10. ADP-Ribosylation and DNA Repair as Induced by Nitrosoureas; I. Introduction; II. Results and Discussion; III. Conclusion; ACKNOWLEDGMENT; References; SECTION II: CLINICAL STUDIES; Chapter 11. Subacute and Chronic Toxicities Associated with Nitrosourea Therapy; I. Introduction; II. Pulmonary Toxicity; III. Renal Toxicity; IV. Other Adverse Effects; V. Conclusions; ACKNOWLEDGMENT; References; Chapter 12. The Toxicity of High-Dose BCNU with Autologous Marrow Support; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion.
V. ConclusionReferences; Chapter 13. Clinical Pharmacology of the Nitrosoureas; I. Introduction; II. General Methods; III. Pharmacokinetic Data; IV. Discussion; V. Conclusion; References; Chapter 14. Nitrosoureas in the Therapy of Hodgkin's Disease; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; References; Chapter 15. Hodgkin's Disease and Malignant Lymphomas; I. Introduction; II. Materials and Methods; III. Results and Discussion; IV. Conclusion; References; Chapter 16. CCNU in Combination Chemotherapy Programs for Small-Cell Lung Cancer.

Related Book Recommendations