Screen LibraryCharacterization of protein therapeutics using mass spectrometry
Protein therapeutics' high efficacy, safety, and ability to treat life-threatening diseases such as cancer, inflammation and genetic disorders have revolutionized modern medicine. In 2012, 200 companies competed in this $90 billion year industry. In Characterization of Protein Therapeutics usin...
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| Literature type: | Electronic eBook |
| Language: | English |
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| Online Access: |
http://dx.doi.org/10.1007/978-1-4419-7862-2 |
| Summary: |
Protein therapeutics' high efficacy, safety, and ability to treat life-threatening diseases such as cancer, inflammation and genetic disorders have revolutionized modern medicine. In 2012, 200 companies competed in this $90 billion year industry. In Characterization of Protein Therapeutics using Mass Spectrometry, expert contributors from academia and industry highlight current approaches and future trends. The book discusses mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies and quantitative approaches. The book also covers various studies involving characterization of process related protein drug impurities/degradants, metabolites, PTMs and higher order structures of protein therapeutics. General practitioners in pharmaceutical research, specialists in analytical sciences, and graduate students studying mass spectrometry and pharmaceutical sciences will find this book useful because of the step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development. |
| Item Description: | Includes index. |
| Carrier Form: | 1 online resource (x, 404 p.) : ill. |
| ISBN: |
9781441978622 (electronic bk.) 1441978623 (electronic bk.) |
| Index Number: | RS431 |
| CLC: | R914 |
| Contents: |
Introduction to Protein Mass Spectrometry / Quantitative Analysis of Therapeutic and Endogenous Peptides using LC/MS/MS Methods / The Development and Implementation of LC/MS-Based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug Discovery / Post-Translationally Modified Proteins: Glycosylation and Disulfide Bond Formation / Mass Spectrometric Characterization in Protein Therapeutics Discovery / Molecular Variants Characterization in Protein Therapeutics Development / Mass Spectrometry of Antibody-Drug Conjugates in Plasma and Tissue in Drug Development / Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization / Fast Photochemical Oxidation of Proteins for Structural Characterization / Applications of Ion Mobility Mass Spectrometry for Characterization of Protein Therapeutics / |