Screen LibraryChemistry and biology of pteridines, 7 : St. Andrews, Scotland, september 21 24, 1982 /
Saved in:
| Corporate Authors: | ; |
|---|---|
| Group Author: | |
| Published: |
De Gruyter,
|
| Publisher Address: | Berlin ; Boston : |
| Publication Dates: |
[2015] ©1983 |
| Literature type: | eBook |
| Language: | English |
| Series: |
Chemistry and biology of pteridines;
7 |
| Subjects: | |
| Online Access: |
http://dx.doi.org/10.1515/9783111619453 http://www.degruyter.com/doc/cover/9783111619453.jpg |
| Item Description: | Includes indexes. |
| Carrier Form: |
1 online resource (xxxiv, 1070 pages) : illustrations. Also available in print edition. |
| ISBN: | 9783111619453 (electronic bk.) |
| CLC: | Q561-53 |
| Contents: |
Adaptation of Folylpolyglutamates to Folate Deprivation in Mouse Hepatoma Cells / Utilization and Loss of Reduced Folates by Human Fibroblasts in Vitro / Factors Affecting Folate Polyglutamate Biosynthesis in Rat Liver / Differential Binding of Folates but not Methotrexate (MTX) by Brush Border (BB) and Basal Lateral (BL) Membranes of Rat Renal Cortex / Biosynthesis of Folate Derivatives in Ehrlich Ascites Carcinoma Cells Grown in Mice and in some Organs of the Host / Variability of Thymidylate Synthetase in Ehrlich Carcinoma Cells and its Role in Resistance to 5-Fluorodeoxyuridine / One-Carbon Metabolism in Human Lymphocytes / Possible Mechanisms of Folate Catabolism / The Intracellular Folate Pool: Studies of Kinetics and Functional Significance / Intestinal Folate Transport. A pH-Dependent, Carrier- Mediated Process / Effects of Folate Depletion on Growth and Survival of Human Cell Line K-562 in Culture / Alterations in Folate Metabolism of the Rat Induced by Acute Ethanol Administration / Participation of Pterins in the Control of Lymphocyte Transformation and Lymphoblast Proliferation / The Pterin Component of the Molybdenum Cofactor (Molybdopt Frontmatter -- Preface -- ACKNOWLEDGEMENTS -- PARTICIPANTS -- Contents -- The Gowland Hopkins Lecture: Transport of Folate and Pterin Compounds / Scottish International Education Trust Lecture: Synthetic Methods in Pteridine Chemistry: Some Applications to Pteridine Natural Products / Synthesis, Chemical and Enzymatic Properties, and Therapeutic Potential of 6,6-Disubstituted Tetrahydroand Quinoid-Dihydro-Pterins / The Structure of Quinonoid Dihydropterins [2-Amino-7,8(6H)-Dihydropteridin-4-ones] / Some Simple s-Triazolopteridines / Linear Tricyclic Analogs of Pteridines / Reactions of Furazano [3,4-djPyrimidines and their Application to Pteridine Synthesis / Syntheses of some Blocked 7,8-Dihydropteridines / Synthesis of Chiral Reduced Pteridine Coenzymes / Report on Discussions / Reactivity of Pteridines / Synthesis and Antitumor Activity of 10-Deazaminopterins / Synthesis and Biological Activity of 5-Deazafolic Acid and 5-Deazaaminopterin / The Nor-Analogues of Folic Acid / Metabolism of Pteridine Cofact Macromolecular Regulation of Sepiapterin and Drosopterin Synthesis in the Purple Mutant of Drosophila / The Hydroxylation of Phenylpropanoids by Euglena gracilis : Role of Pteridines / Studies with Old Yellow Enzyme, Reconstitution with Lumazine Analogs as Coenzyme / Biosynthesis of Riboflavin / Metabolism and Function of Pterin Compounds in Seed Germination / Thymidylate Synthetase During Proliferation and Differentiation of Physarum polycephalum / Influence of Vitamin B12 on Folate Metabolism in Lactobacillus Leichmannii / High-Affinity Binding of Folate to a Small and Large Molecular Size Protein from Human Milk / High-Affinity Folate Binding in Leukocytes from Normal Subjects Displays Positive Cooperativity, and the Affinity Depends on the Protein Concentration / Characteristics of 5-Methyltetrahydrofolate Binding to the Folate-Binding Protein from Cow's Whey / Interactions of Folate-Dependent Enzymes of DNA Precursor Metabolism in T4 Phage-Infected Bacteria / The Regulation of Biopterin Biosynthesis in the Rat / Biosynthesis of Tetrahydrobiopterin in Mammalian Tissues by De Novo and Salvage Pathways / Perspectives on Tetrahydrobiopterin Biosynthesi Speculation on the Mechanism of Therapeutic Action of Tetrahydrobiopterin in Human Disease / Correlation of Tetrahydrobiopterin Content and Guanosine Triphosphate Cyclohydrolase Activity in Cells and Tissues / Unconjugated Pteridines in Human Physiological Fluids. Normal and Pathological Profiles / Biopterin and Phenylalanine Metabolism During Early Liver Regeneration / GTP-Cyclohydrolase Activities in Rat Liver / Phenylalanine Hydroxylase Assay Using Biopterin and Synthetic Pteridine / Dihydropteridine Reductase Levels in Human Normal and Neoplastic Tissues / Investigations of Tissue Folates in Normal and Malignant Tissues / Blood Cell Biopterin as an Indicator of Transplanation- Induced Hemopoiesis and Leukemic Cell Proliferation / Assessment of Urinary Neopterin in the Early Diagnosis of Human Allograft Rejection / Behaviour of Neopterin Levels in Patients with Haematological and Gynaecological Neoplasms / Pteridines in Dictyostelium discoideum and Physarum polycephalum / Structure, Function and Affinity Labelling Studies of Dihydrofolate Reductase / Methylene Tetrahydrofo ate Reductase: Studies in a Human Mutant and Mammalian Liver / Studies on Methylenetetrahydrofolate Reductase from Pig Liver: Catalytic Mechanism and Regulation by Adenosylmethionine / Role of Methylenetetrahydrofolic Acid Reductase in Regulation of Folic Acid Metabolism and its Relation to the Methyl Trap Hypothesis / The Mechanism of Action of the Transformylase Enzymes / Folypolyglutamate Synthesis in Neurospora Crassa / Folates and Cancer Chemotherapy / Inability to Increase the Mobilisation of Liver Folates During Folate Deficiency Suggesting that this and Other Organs do not act as a Potential Folate Store for Marrow and Other Rapidly Proliferating Cells / A High Molecular Weight Nonfunctional Immunoreactive Form of Dihydrofolate Reductase in L1210 Leukaemia Cells / Further Characterization of the Pterdine Binding Variant of Alphas-Acid Glycoprotein, Accumulated in the Blood of Patients with Malignant Diseases / Structure-Activity Relationships among 5-Substituted Lipophilic Diaminopyrimidine Antineoplastic Antifolates / Attempts to De The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis / The Role of Pteridines in Regulation of Growth / Evidence for a Folate Bound to Rat Hepatic Uroporphyrinogen III Cosynthase and its Role in the Biosynthesis of Heme / Aerobic Oxidation of 5,6,7,8-Tetrahydroneopterin / The Conformations of 7,8 (6H)-Dihydropterin Substrates and the Activity of Dihydropteridine Reductase (E.C.1.6.99.10) / Dihydrofolate Reductase: The Stereochemistry of Inhibitor Selectivity / Synthesis of an 8-Deaza Analog of the Intermediate in the Thymidylate Synthetase Reaction (1) / The Synthesis of Analogs of Pteroylglatamyl-y-Phosphate as Potential Inhibitors of Folylpolyglutamate Synthetase / Synthesis and Activity of 8,10-Dideazaminopterin / CNDO/2 Molecular Orbital Calculations on the Antifolate DAMP and Some of its Analogues: Conformational Characteristics / Fluorescent Analogues of Methotrexate as Probes for Folate Antagonist Molecular Receptors / Dihydrofolate Reductase Overproduction Identified by Flow Cytometry Using a Fluorescent Methotrexate Analogue / X-Ray Studies of the Binding of Trimethoprim, Methotrexate, Pyrimethamine and Two Trimethoprim Analogues to Bacterial Dihydrofolate Reductase / A New Spectrophotometry Method for the Assessment of Tight Binding Benzyldiaminopyrimidine Inhibitors of Dihydrofolate Reductase / Two Interconverting Conformers of a Drug-Receptor Complex: The Lactobacillus Casei Dihydrofolate Reductase-NADP / Multiple Conformations of the Dihydrofolate Reductase- Folate-NADP / The Three-Dimensional Structure of Mouse L1210 Dihydrofolate Reductase / Isolation and Amino Acid Sequence Studies of Dihydrofolate Reductase from Neisseria Gonorrhoeae / Purification of 7,8-Dihydropteroate-Synthetase from E. Coli by Affinity- and Hydrophobic Interaction Chromatography / Isolation and Characterization of an E. Coli Mutant Affected in Dihydrofolate- and Folylpolyglutamate- Synthetase / Purification and Properties of 5-Formyltetrahydrofolate Cyclodehydrase from Rabbit Liver / Structural Studies on Formyl-Methenyl-Methylene Tetrahydrofolate Synthetase from Rabbit Liver / Utilization of Folate Polyglutamate for Growth by Lactobacillus Casei / Folate and Folate Enzymes as Structural Components of Bacteriophage Particles / |