Screen LibraryLesions and transplantation /
Methods in Neurosciences, Volume 7: Lesions and Transplantation describes the chemical and nonchemical production of lesions and preparation and development of transplants, implants, and grafts. This book consists of four sections-chemical and nonchemical lesioning; model systems utilizing lesioning...
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| Corporate Authors: | |
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| Group Author: | |
| Published: |
Academic Press,
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| Publisher Address: | San Diego, Calif. : |
| Publication Dates: | [1991] |
| Literature type: | eBook |
| Language: | English |
| Series: |
Methods in neurosciences ;
volume 7 |
| Subjects: | |
| Online Access: |
http://www.sciencedirect.com/science/bookseries/10439471/7 |
| Summary: |
Methods in Neurosciences, Volume 7: Lesions and Transplantation describes the chemical and nonchemical production of lesions and preparation and development of transplants, implants, and grafts. This book consists of four sections-chemical and nonchemical lesioning; model systems utilizing lesioning; transplants, implants, and grafts; and assessment of lesions and transplants. In these sections, this volume discusses the excitotoxins as tools for producing brain lesions; use of acromelic acid for production of rat spinal lesions; and opioid and nonopioid antinociception as revealed by lesion. |
| Carrier Form: | 1 online resource (xvii, 496 pages) : illustrations. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9781483259505 1483259501 |
| Index Number: | QP361 |
| CLC: | R338 |
| Contents: |
Front Cover; Lesions and Transplantation; Copyright Page; Table of Contents; Preface; Methods in Neurosciences; Section I: Chemical and Nonchemical Lesioning; Chapter 1. Lesioning of Rat Nigrostriatal Dopamine Pathway with l-Methyl-4-phenylpyridinium Ion (MPP+); Introduction; Methods; Evaluation of the Lesion; Conclusion; References; Chapter 2. Excitotoxins as Tools for Producing Brain Lesions; Introduction; Excitotoxins: Classification, Comparison, and Mechanisms; Use of Excitotoxins to Make Lesions; Summary; Acknowledgments; References; Chapter 3. Excitotoxin-Lesioned Rat Striatum; Methods AcknowledgmentsReferences; Chapter 4. Use of Acromelic Acid for Production of Rat Spinal Lesions ; Acromelic Acid; Injection of Acromelic Acid into Rats and Mice; Kainoid Neurotoxicity; Electrophysiological and Pharmacological Basis; Behavioral Basis; Histological Basis; References; Chapter 5. Use of Ibotenic Acid to Selectively Lesion Brain Structures ; Methods and Procedures; Additional Considerations; Is There Damage to Fibers of Passage following IBO Injections?; Conclusions; Acknowledgments; References; Chapter 6. Monosodium Glutamate (MSG) Lesions; Introduction; Mechanism of Action Histology of LesionsProcedures; MSG Syndrome; Histochemical Changes; Summary; References; Chapter 7. Comparison of Electrolytic and Radio-Frequency Lesion Methods; Introduction and Historical Background; Different Effects Observed with Electrolytic and Radio-Frequency Lesions; Production of Electrolytic Lesions; Production of Radio-Frequency Lesions; Production and Verification of Lesions That Leave No Metallic Ion Deposits; Summary and Conclusion; References; Chapter 8. Use of Cold to Reversibly Suppress Local Brain Function in Behaving Animals ; Moveable Cryodes Permanently Implanted CryodesAcknowledgment; References; Chapter 9. Chorioretinal Photocoagulation by Different Laser Sources; Introduction; Photocoagulation; Laser Power; Exposure Time; Spot Size; Laser Photocoagulators; Transpupillary Photocoagulation; Transscleral Photocoagulation; Endoocularphotocoagulation; References; Chapter 10. Production of Reversible Local Blockage of Neuronal Function; Introduction; Local Cooling of the CNS; Local Anesthesia; Other Chemicals; Summary; References; Chapter 11. Lesioning the Nucleus Basalis; Introduction; Lesioning Methods; Conclusions; References Section II: Model Systems Utilizing LesioningChapter 12. Unilateral MPTP-Lesioned Monkey as an Animal Model for Parkinson's Disease; Parkinson's Disease; 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP); Bilateral versus Unilateral MPTP-Treated Monkeys; MPTP Application; The Unilateral MPTP-Lesioned Monkey; Conclusions; Acknowledgments; References; Chapter 13. MPTP-Induced Parkinsonism in Nonhuman Primates ; Species; MPTP Administration; Clinical Outcome of MPTP Administration; Histological Changes after MPTP Administration; Neurochemical Changes after MPTP Administration |