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Adenosine receptors in neurodegenerative diseases /

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Bibliographic Details
Corporate Authors: Elsevier Science & Technology.
Group Author: Blum, David; Lopes, Lu isa V.
Published: Academic Press is an imprint of Elsevier,
Publisher Address: London, United Kingdom :
Publication Dates: 2017.
Literature type: eBook
Language: English
Subjects:
Adenosine > Receptors.
Nervous system > Degeneration > Molecular aspects.
Receptors, Purinergic P1.
Adenosine.
Neurodegenerative Diseases.
Receptor, Adenosine A2A.
SCIENCE > Biochemistry. > Biochemistry.
Nervous system > Molecular aspects. > Molecular aspects.
Electronic books.
Fulltext.
Internet Resources.
Online Access: https://www.sciencedirect.com/science/book/9780128037249
Item Description: Includes index.
Carrier Form: 1 online resource
Bibliography: Includes bibliographical references and index.
ISBN: 9780128037454
0128037458
Index Number: QP625
CLC: Q525-532
Contents: Front Cover; Adenosine Receptors in Neurodegenerative Diseases; Copyright Page; Dedication; Contents; List of Contributors; Foreword and History of Adenosine in the Central Nervous System; References; Acknowledgments; I. Physiology; 1 Adenosine Receptor Biology in the Central Nervous System; Sources of Adenosine in the CNS; Receptor Subtypes and Their CNS Distribution; A1 Adenosine Receptors; A2A Adenosine Receptors; A2B Adenosine Receptors; A3 Adenosine Receptors; Crosstalk With Other Receptors; Adenosine and CNS Diseases; Recent Clinical Trials; A1 Adenosine Receptors.
A2A Adenosine ReceptorsA2B Adenosine Receptors; A3 Adenosine Receptors; References; 2 Adenosine Signaling Throughout Development; Introduction; Effects of Adenosine Signaling and Its Dysfunction in CNS; Effects of Adenosine in Oligodendrocytes Development; Effects of Adenosine on Cardiovascular System During Embryogenesis; Postnatal Effects of Adenosine on Cardiovascular System; Postnatal Effect of Adenosine on Respiratory System; Use of Methylxanthines in Premature Babies; Postnatal Effects of Adenosine on the Genitourinary System; Postnatal Effect of Adenosine on the Enteric System.
Postnatal Effect of Adenosine on Other SystemsConclusion; References; 3 Influence of Adenosine on Synaptic Excitability; Introduction; Molecular & Physiological Mechanisms; Influence on Neurotransmitter Availability and Basal Synaptic Transmission; Adenosine Tunes the Responses of Postsynaptic Glutamate and GABA Receptors; Astrocyte-Derived Adenosine Controls Basal Synaptic Transmission and the Available Range for Plasticity Control; Metamodulation by Adenosine: Impact on Synaptic Plasticity; Adenosine Shapes Synapses for Plasticity; Implications for Epilepsy; Pathophysiological Mechanisms.
Adenosine Receptor-Dependent EffectsAdenosine Receptor-Independent Effects; Disruption of Adenosine Homeostasis in Epilepsy; Comorbidities of Epilepsy; Therapeutic Implications; Conclusions and Outlook; Acknowledgments; References; 4 Regulation of Synaptic Transmission by Adenosine at the Neuromuscular Junction; Introduction; Neuromuscular Junction; Structural Organization of the Neuromuscular Junction; Neuromuscular Transmission; Coexistence of Transmitters and Neuromodulators; Adenosine as a Neuromodulator at the Neuromuscular Junction.
Pathways: Synthesis and Degradation of Adenosine at the Neuromuscular JunctionAdenosine Receptors; Nerve Terminals; Schwann Cells; Adenosine Receptors and Their Interactions With Other Receptors at the Neuromuscular Junction; Crosstalk Between A1 and A2A Receptors; Crosstalk Between Adenosine Receptors and Acetylcholine Receptors; Adenosine Receptors and BDNF Actions; Adenosine Signaling in Ageing and Disease; Conclusions; References; 5 Gene Regulation of Adenosine A2A Receptors in the Central Nervous System; General Introduction; A2AR Promoter and Gene Structure; Epigenetics of ADORA2A.

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