Screen LibraryApoptosis, senescence, and cancer
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| Group Author: | ; ; |
|---|---|
| Published: |
Humana Press,
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| Publisher Address: | Totowa, N.J. |
| Publication Dates: | c2007. |
| Literature type: | Book |
| Language: | English |
| Edition: | 2nd ed. |
| Series: |
Cancer drug discovery and development |
| Subjects: | |
| Carrier Form: | xvii, 599 p.: ill. ; 26 cm. |
| ISBN: |
1588295273 (alk. paper) 9781588295279 (alk. paper) |
| Index Number: | R329 |
| CLC: | R329.2 |
| Call Number: | R329.2/A644-6/2nd.ed. |
| Contents: |
Available to OhioLINK libraries. Includes bibliographical references and index. The intrinsic pathway of apoptosis -- The extrinsic pathway of apoptosis -- Evaluating the importance of apoptosis and other determinants of cell death and survival -- Mitotic catastrophe -- Autophagy and autophagic cell death -- Regulation and function of detachment-induced cell death (anoikis) in cancer progression and metastasis -- Structure and function of the telomere -- Overview of senescence -- Contributions of telomerase to tumorigenesis -- The role of telomeres in genomic instability -- Overview of the DNA damage checkpoint: ATM and ATR -- Interactions between myc- and cyclin-dependent kinase inhibitors in cancer -- Interplay between [gamma]H2AX and 53BP1 pathways in DNA double-strand break repair response -- DNA-dependent protein kinase in repair, apoptosis, telomere maintenance, and chemotherapy -- Resistance/signaling pathways -- Ceramide and multidrug resistance -- Chemo- and radiosensitization through inhibition of PI3K/Akt signaling -- The advancement of epidermal growth factor receptor inhibitors in cancer therapy -- Antimetabolites -- Topoisomerase I poisons and apoptotic topoisomerase I-DNA complexes -- Perturbations of cellular functions by topoisomerase II inhibitors: all roads lead to cell death? -- The significance of poly-targeting in apoptosis induction by alkylating agents and platinum drugs -- Contributions of apoptosis and senescence to cytotoxicity produced by microtubule-stabilizing agents -- Tyrosine kinase inhibitors -- Monoclonal antibodies in lymphomas -- Role of apoptosis in anti-angiogenic cancer therapies -- Photodynamic therapy-induced apoptosis -- Modulation of TRAIL signaling for cancer therapy. |