Screen LibraryBiomaterials associated infection : immunological aspects and antimicrobial strategies /
Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious...
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| Corporate Authors: | |
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| Group Author: | ; ; |
| Published: |
Springer,
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| Publisher Address: | New York, NY : |
| Publication Dates: | 2013. |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
http://dx.doi.org/10.1007/978-1-4614-1031-7 |
| Summary: |
Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices. Provides a clinical perspective to set research directionsSummarizes the pathogenicity of the most common bacterial species isolated in BAICovers both biofilms and tissue reservoirs as modes of infectionPresents state-of-the-art issues of immune function in the vicinity of implanted biomaterialsDescribes the latest technologies for antimicrobial activation of biomaterials |
| Carrier Form: | 1 online resource |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9781461410317 (electronic bk.) 1461410312 (electronic bk.) |
| Index Number: | R857 |
| CLC: | R318.08 |
| Contents: |
The Pathogenesis of Medical Device associated Infection -- Biomaterial-Associated Infection: A Perspective from the Clinic / Staphylococcus epidermidis in Biomaterial-Associated Infections / Staphylococcal Virulence Factors / Propionibacterium acnes: An Emerging Pathogen in Biomaterial-Associated Infection / Bridging the Gap Between In Vitro and In Vivo Evaluation of Biomaterial-Associated Infections / Biomaterial-Dependent Characteristics of the Foreign Body Response and S. epidermidis Biofilm Interactions / Dendritic Cell-Biomaterial Interactions: Implications for the Onset and Development of the Foreign Body Response / Tissue Colonization in Biomaterial-Associated Infection / Systemic Treatment Options for Medical Device-Associated Infection / Preventive Measures Against Transcutaneous Device Infections / Infections Associated with Implanted Dental Devices / Animal Models of Orthopedic Implant-Related Infection / Biomaterial-Based Strategies to Reduce Medical Device-Associated Infection -- Antimicrobial Medical Devices in Preclinical Development and Clinical Use / Silver Containing Biomaterials / Quaternary Ammonium Compounds / Anti-adhesive and Antibacterial Polymer Brushes / Clinical applications, case studies -- Infection in Fracture Fixation: Device Design and Antibiotic Coatings Reduce Infection Rates / The Indwelling Bladder Catheter: Attempts to Prevent Infection and the Development of Bacterial Biofilms / Antimicrobial-Modified Vascular Catheters / Topical Antimicrobial-Containing Biomaterials for Peri-Implant Infections in the Oral Cavity / Preventive Strategies in VAP: Focus on Silver-Coated Endotracheal Tubes / |