Screen LibraryProtein-protein interactions in drug discovery
Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of prote...
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| Published: |
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| Literature type: | Electronic eBook |
| Language: | English |
| Series: |
Methods and principles in medicinal chemistry ;
v. 56 |
| Subjects: | |
| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/9783527648207 |
| Summary: |
Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the devel. |
| Carrier Form: | 1 online resource (xxi, 314 p.) : ill. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9783527648238 (e-book) 3527648232 (e-book) 9783527648207 3527648208 |
| Index Number: | QP551 |
| CLC: | Q51 |
| Contents: | Protein-protein interactions: an vverview / Christian Ottman -- Prediction of intra- and interspecies protein-protein interactions facilitating systems biology studies / Sylvia Schleker, Seshan Ananthasubramanian, Judith Klein-Seetharaman, Madhavi K Ganapathiraju -- Modulators of protein-protein interactions: importance of three-dimensionality / David C Fry, Sung-Sau So -- A leap into the chemical space of protein-protein interaction inhibitors / Bruno O Villoutreix, C Labbé, David Lagorce, Guillaume Laconde, Olivier Sperandio -- Interactive technologies for leveraging the known chemistry |