Screen LibraryCell polarity in development and disease /
Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss...
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| Corporate Authors: | |
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| Group Author: | |
| Published: |
Academic Press, an imprint of Elsevier,
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| Publisher Address: | London, UK : |
| Publication Dates: |
[2018] ©2018 |
| Literature type: | eBook |
| Language: | English |
| Series: |
Perspectives in translational cell biology
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| Subjects: | |
| Online Access: |
http://www.sciencedirect.com/science/book/9780128024386 https://www.sciencedirect.com/science/book/9780128024386 |
| Summary: |
Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research. |
| Carrier Form: | 1 online resource. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9780128125915 0128125918 |
| Index Number: | QH604 |
| CLC: | Q2 |
| Contents: |
Cell Polarity in Oocyte Development / Introduction -- Oogenesis and the Establishment of Animal -- Vegetal Polarity -- Origin of Animal -- Vegetal Polarity During Oogenesis -- Xenopus -- Zebrafish -- Mouse -- Polarity and the Ovarian Stem Cell -- Structural Basis for Mitochondrial Cloud/Balbiani Formation -- Macf1 -- Buckyball -- Generation of Cortical Polarity in the Oocyte and Egg -- Cortical Polarity and Sperm Entry -- Apical -- Basal Polarization of the Xenopus Egg -- Cortical Polarity and Superficial Cell Fate -- Concluding Remarks -- Acknowledgments -- References -- Pluripotency -- What Does Cell Polarity Have to Do With It / Mammalian Pluripotency -- Cell Polarity in the Mammalian Embryo -- Emergence of Pluripotency in the Mouse Embryo -- Cell Polarity in the Mammalian Early Embryo -- How Cell Polarity Regulates Establishment of Pluripotency in the Mouse Embryo -- Cell Polarity and Embryo-Derived Pluripotent Stem Cell Lines -- Multiple States of Pluripotency -- Polarization of Pluripotent Stem Cell Lines -- Cell Polarization During Somatic Cell Reprogramming -- Conclusions -- Cell Polarity and Asymmetric Cell Division by the Wnt Morphogen / Binary Cell Fate Specification via Asymmetric Cell Division -- PAR Proteins Polarize Caenorhabditis elegans Zygotes -- Delta/Notch Signaling Drives Asymmetric Cell Division in Fly Neuroblasts -- Morphogens as Cell Polarizers -- Wnt/ I(0x1B)p2(0x1B)s-Catenin Signal Transduction -- Wnt/ I(0x1B)p2(0x1B)s-Catenin Asymmetry and Asymmetric Cell Division in Caenorhabditis elegans -- Caenorhabditis elegans Epidermal Seam Stem Cell Lineage Undergoes Reiterative Asymmetric Cell Divisions -- Asymmetric Cell Divisions in the Caenorhabditis elegans Seam Require Wnt Signaling -- SYS-1/ I(0x1B)p2(0x1B)s-Catenin Inheritance Is Limited by Ce |