Screen LibraryThe hERG cardiac potassium channel structure, function, and long QT syndrome.
This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding.℗¡It features regulatory authority perspectives on preferred preclinical test systems and include...
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| Corporate Authors: | ; |
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| Group Author: | ; |
| Published: |
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| Literature type: | Electronic eBook |
| Language: | English |
| Series: |
Novartis Foundation symposium ;
266 |
| Subjects: | |
| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/047002142X |
| Summary: |
This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding.℗¡It features regulatory authority perspectives on preferred preclinical test systems and includes topics on℗¡hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. |
| Item Description: |
Proceedings of the Symposium on The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome, held at Novartis Foundation, London, May 4-6, 2004. Editors: Derek J. Chadwick, Jamie Goode. |
| Carrier Form: | 1 online resource (ix, 297 pages) : illustrations. |
| Bibliography: | Includes bibliographical references and indexes. |
| ISBN: |
0470021411 9780470021415 0470021403 9780470021408 047002142X 9780470021422 |
| Index Number: | QP114 |
| CLC: | R54-33 |
| Contents: | Gating and assembly of heteromeric hERG1a/1b channels underlying IKr in the heart / Gail A. Robertson, Eugenia M.C. Jones and Jinling Wang -- Structure-function studies of the outer mouth and voltage sensor domain of hERG / Gea-Ny Tseng and H. Robert Guy -- Voltage sensor movement in the hERG K channel / David R. Piper, Michael C. Sanguinetti and Martin Tristani-Firouzi -- hERG channel trafficking / Eckhard Ficker, Adrienne Dennis, Yuri Kuryshev, Barbara A. Wible and Arthur M. Brown -- Dynamic control of hERG/IKr by PKA-mediated interactions with 14-3-3 / Anna Kagan and Thomas V. McDonald -- Does hERG coassemble with a [beta] subunit? Evidence for roles of MinK and MiRP1 / Arun Anantharam and Geoffrey W. Abbott -- hERG block, QT liability and sudden cardiac death / Arthur M. Brown -- Structural determinants for high-affinity block of hERG potassium channels / John Mitcheson, Matthew Perry, Phillip Stansfeld, Michael C. Sanguinetti, Harry Witchel and Jules Hancox -- Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs / Michael C. Sanguinetti, Jun Chen, David Fernandez, Kaichiro Kamiya, John Mitcheson and José A. Sanchez-Chapula -- In silico modelling : pharmacophores and hERG channel models / Maurizio Recanatini, Andrea Cavalli and Matteo Masetti -- The long QT syndrome : a clinical counterpart of hERG mutations / Peter J. Schwartz -- Cellular mechanisms of Torsade de Pointes / Steven Poelzing and David S. Rosenbaum -- Expression and role of hERG channels in cancer cells / Annarosa Arcangeli -- TRIad, foundation for proarrhythmia (triangulation, reverse use dependence and instability) / Luc M. Hondeghem -- Drug-induced QT interval prolongation : regulatory guidance and perspectives on hERG channel studies / Rashmi R Shah. |