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Handbook of basic pharmacokinetics-- including clinical applications

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Bibliographic Details
Main Authors: Ritschel W. A. (Wolfgang A.)
Corporate Authors: American Pharmaceutical Association.
Group Author: Kearns Gregory L.
Published: American Pharmacists Association,
Publisher Address: Washington, D.C.
Publication Dates: c2004.
Literature type: Book
Language: English
Edition: 6th ed.
Subjects:
Pharmacokinetics.
Clinical pharmacology.
Carrier Form: xii, 432 p.: ill. ; 26 cm.
ISBN: 1582120544 (hc.)
Index Number: R969
CLC: R969.1-62
R912-62
Call Number: R969.1-62/R612/6th.ed.
Contents: Includes bibliographical references and index.
Definitions and glossary -- The LADMER system: liberation, absorption, distribution, metabolism, elimination, and response -- Organs, tissues, cells, and organelles -- Cell membranes -- Drug-receptor interactions -- Absorption/transport mechanisms -- pKa and degree of ionization -- Lipid/water partition coefficient -- Physicochemical factors altering biological performance of drugs -- Biopharmaceutical data of the gastrointestinal tract -- Fluid compartments and circulatory system -- Binding of drugs to biological material -- Drug biotransformation -- Compartment models -- Determination of rate constants -- Volume of distribution and distribution coefficient -- Excretion and clearance of drugs -- Urinary and biliary recycling. Cumulative urinary excretion -- Area under the blood level-time curve -- Pharmacokinetics of single dose administration -- Pharmacokinetics of multiple dosing -- Compartment model independent analysis -- Pediatric pharmacokinetics -- Drug dosage in elderly patients -- Drug dosage in obese patients -- Drug disposition in pregnancy -- Dosage regimen design -- Drug monitoring and dosage adjustment -- Physiological and pathological factors influencing drug response -- First dosage size in man -- Forensic pharmacokinetics -- Nonlinear pharmacokinetics -- Curve fitting -- Correlation of clinical response with drug disposition -- Bioavailability and bioequivalence -- Body surface areas -- Extracorporeal methods of drug removal -- Pharmacogenetics and pharmacogenomics.

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