Handbook of basic pharmacokinetics-- including clinical applications
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Main Authors: | |
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Corporate Authors: | |
Group Author: | |
Published: |
American Pharmacists Association,
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Publisher Address: | Washington, D.C. |
Publication Dates: | c2004. |
Literature type: | Book |
Language: | English |
Edition: | 6th ed. |
Subjects: | |
Carrier Form: | xii, 432 p.: ill. ; 26 cm. |
ISBN: | 1582120544 (hc.) |
Index Number: | R969 |
CLC: |
R969.1-62 R912-62 |
Call Number: | R969.1-62/R612/6th.ed. |
Contents: |
Includes bibliographical references and index. Definitions and glossary -- The LADMER system: liberation, absorption, distribution, metabolism, elimination, and response -- Organs, tissues, cells, and organelles -- Cell membranes -- Drug-receptor interactions -- Absorption/transport mechanisms -- pKa and degree of ionization -- Lipid/water partition coefficient -- Physicochemical factors altering biological performance of drugs -- Biopharmaceutical data of the gastrointestinal tract -- Fluid compartments and circulatory system -- Binding of drugs to biological material -- Drug biotransformation -- Compartment models -- Determination of rate constants -- Volume of distribution and distribution coefficient -- Excretion and clearance of drugs -- Urinary and biliary recycling. Cumulative urinary excretion -- Area under the blood level-time curve -- Pharmacokinetics of single dose administration -- Pharmacokinetics of multiple dosing -- Compartment model independent analysis -- Pediatric pharmacokinetics -- Drug dosage in elderly patients -- Drug dosage in obese patients -- Drug disposition in pregnancy -- Dosage regimen design -- Drug monitoring and dosage adjustment -- Physiological and pathological factors influencing drug response -- First dosage size in man -- Forensic pharmacokinetics -- Nonlinear pharmacokinetics -- Curve fitting -- Correlation of clinical response with drug disposition -- Bioavailability and bioequivalence -- Body surface areas -- Extracorporeal methods of drug removal -- Pharmacogenetics and pharmacogenomics. |