Screen LibraryDrug bioavailability estimation of solubility, permeability, absorption and bioavailability /
The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane perm...
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| Group Author: | ; ; |
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| Published: |
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| Literature type: | Electronic eBook |
| Language: | English |
| Series: |
Methods and principles in medicinal chemistry ;
v. 18 |
| Subjects: | |
| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/3527601473 |
| Summary: |
The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its s |
| Carrier Form: | 1 online resource (xxiv, 579 pages) : illustrations. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
3527601473 9783527601479 3527605150 9783527605156 |
| Index Number: | RM301 |
| CLC: | R452 |
| Contents: | Physico-chemical approaches to drug absorption / Han van de Waterbeemd -- High-throughput measurement of log D and pKa / Dr. John E.A. Comer -- High-throughput measurement of permeability profiles -- Alex Avdeef -- Caco-2 and emerging alternatives for prediction of intestinal drug transport : a general overview / Per Artursson and Staffan Tavelin -- Cell cultures in drug discovery : an industrial perspective / Anna-Lena Ungell and Johan Karlsson -- Use of animals for the determination of absorption and bioavailability / Chris Logan -- In vivo permeability studies in the gastrointestinal trac |