Screen LibraryDrug bioavailability estimation of solubility, permeability, absorption and bioavailability /
The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane perm...
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| Group Author: | ; ; |
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| Published: |
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| Literature type: | Electronic eBook |
| Language: | English |
| Series: |
Methods and principles in medicinal chemistry ;
v. 18 |
| Subjects: | |
| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/3527601473 |
| Summary: |
The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so- |
| Carrier Form: | 1 online resource (xxiv, 579 pages) : illustrations. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
3527601473 9783527601479 3527605150 9783527605156 |
| Index Number: | RM301 |
| CLC: | R452 |
| Contents: | Physico-chemical approaches to drug absorption / Han van de Waterbeemd -- High-throughput measurement of log D and pKa / Dr. John E.A. Comer -- High-throughput measurement of permeability profiles -- Alex Avdeef -- Caco-2 and emerging alternatives for prediction of intestinal drug transport : a general overview / Per Artursson and Staffan Tavelin -- Cell cultures in drug discovery : an industrial perspective / Anna-Lena Ungell and Johan Karlsson -- Use of animals for the determination of absorption and bioavailability / Chris Logan -- In vivo permeability studies in the gastrointestinal tract of humans / Niclas Petri and Hans Lennernäs -- Gastrointestinal dissolution and absorption of drugs / Gladys E. Granero, Chandrasekharan Ramachandran, and Gordon L. Amidon -- Aqueous solubility in discovery, chemistry, and assay changes / Chris Lipinski -- Factors influencing the water solubilities of crystalline drugs / James W. McFarland, Chau M. Du, and Alex Avdeef -- Transporters in the GI tract / Ho-Chul Shin [and others] -- Hepatic transport / Hiroshi Suzuki and Yuichi Sugiyama -- The importance of gut wall metabolism in determining drug bioavailability / Kevin Beaumont -- Modified cell lines / Charles L. Crespi -- Intestinal absorption : the role of polar surface area / Per Artursson and Christel A.S. Bergström -- Calculated molecular properties and multivariate statistical analysis in absorption prediction / Ulf Norinder and Markus Haeberlein -- VOLSURF : a tool for drug ADME-properties prediction / Gabriele Cruciani [and others] -- Simulation of absorption, metabolism, and bioavailability / Michael B. Bolger [and others] -- Prediction of bioavailability / Arun K. Mandagere and Barry Jones -- Towards P-glycoprotein structure-activity relationships / Anna Seelig [and others] -- Application of the biopharmaceutical classification system now and in the future / Bertil Abrahamsson and Hans Lennernäs -- Prodrugs / Bente Steffansen, Anne Engelbrecht Thomsen, and Sven Frokjaer -- Modern delivery strategies : physiological considerations for orally administered medications / Clive G. Wilson. |