Screen LibraryRenaissance of sickle cell disease research in the genome era /
The Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, a...
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| Main Authors: | |
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| Published: |
Imperial College Press ; Distributed by World Scientific Pub. Co.,
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| Publisher Address: | London : Singapore : |
| Publication Dates: | 2007. |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
http://www.worldscientific.com/worldscibooks/10.1142/P443#t=toc |
| Summary: |
The Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, and community concerns of health disparity to educate professionals, students and the general public about meeting this challenging expectation. Contributions from physicians, research scientists, scientific administrators and community workers make Renaissance of Sickle Cell Disease Research in the Genome Era unique among the catalogue of books on this genetic disorder. Part 1 offers detailed review of the National Heart Lung and Blood Institute's leadership role in funding sickle cell research, as well as developing progressive research initiatives and the predicted impact of the Human Genome Project. Part 2 gives an account of several clinical research perspectives based on the Cooperative Study of Sickle Cell Disease. These include recommendations for newborn screening, pain management, stroke, transfusion therapy and pediatric and adult healthcare. Part 3 offers novel insights into basic science research progress and the impact of the Human Genome Project on the direction of hemoglobinopathy research, including hemoglobin switching, bone marrow transplantation and gene therapy. Part 4 engages the reader in a culture-based discussion of the stigma attached to sickle cell disease in the African American community and the apprehensions about genetic research in this community. It concludes with a global perspective on sickle cell disease from African, European and American experiences. For readers seeking a definitive account of sickle cell disease appropriate for students, researchers and community workers, this collaborative effort is an ideal textbook. |
| Carrier Form: | 1 online resource (xxxv,357pages) : illustrations (some color) |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9781860947964 (electronic bk.) |
| CLC: | R556 |
| Contents: | 1. Sickle cell disease: demystifying the beginnings / Clarice Reid and Griffin Rodgers -- 2. Sponsorship of sickle cell disease research by the National Institutes of Health: a brief history and projections for the future / Gregory L. Evans and David G. Badman -- 3. The human genome project / Betty S. Pace -- 4. Sickle cell disease: a phenotypic patchwork / Kim Smith-Whitley and Betty S. Pace -- 5. Preventive care and advances in the treatment of sickle cell disease / Charles T. Quinn and George R. Buchanan -- 6. Sickle cell disease in adults / Johnson Haynes, Jr. and Ardie Pack-Mabien -- 7. Pain in sickle cell disease: a multidimensional construct / Lennette J. Benjamin and Richard Payne -- 8. Transfusion therapy in sickle cell disease / Carolyn Hoppe, Robert Adams and Elliot Vichinsky -- 9. Hemoglobin S polymerization, just the beginning / Frank A. Ferrone -- 10. Damage to the red blood cell membrane in sickle cell disease / Steven R. Goodman and Clinton Joiner -- 11. Fetal hemoglobin for what ails sickle haemoglobin / Solomon F. Ofori-Acquah and Betty S. Pace -- 12. Genetic modulation of sickle cell disease / Martin H. Steinberg and Swee Lay Thein -- 13. Molecular framework of hemoglobin switching / Steven Fiering -- 14. Dynamic nucleoprotein structure of the [symbol]-globin locus: establishing a rational molecular basis for therapeutic modulation of hemoglobin switching / Emery Bresnick ... [et al.] -- 15. Vertebrate models for sickle cell disease research / Barry H. Paw ... [et al.] -- 16. Stem cell biology / Wei Li and Alan W. Flake -- 17. Bone marrow transplantation / Robert I. Raphael and Mark C. Walters -- 18. Genetically engineered cures: gene therapy for sickle cell disease / Punam Malik and Philippe Leboulch -- 19. Sickle cell disease: the past, present and future social and ethical dilemmas / Vence L. Bonham, Jr., Carlton Haywood, Jr. and Vanessa Northington Gamble -- 20. It takes a village to cure sickle cell disease / Rosie Peterson and Denise Davis-Maye -- 21. Beyond national borders: a global perspective on advances in sickle cell disease research and management, and new challenges in the genome era / Solomon F. Ofori-Acquah and Kwaku Ohene-Frempong. |