Screen LibraryFragment-based drug discovery a practical approach /
Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechn...
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| Group Author: | ; |
| Published: |
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| Literature type: | Electronic eBook |
| Language: | English |
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| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/9780470721551 |
| Summary: |
Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. ℗¡ Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, |
| Carrier Form: | 1 online resource (ix, 285 pages) : illustrations |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9780470721551 0470721553 9780470721568 0470721561 1282342754 9781282342750 |
| Index Number: | RM301 |
| CLC: | R914.2 |
| Contents: | Introduction to fragment-based drug discovery / Mike Cherry and Tim Mitchell -- Designing a fragment process to fit your needs / Edward R. Zartler and Michael J. Shapiro -- Assembling a fragment library / Mark Brewer [and others] -- Practical aspects of using NMR in fragment-based screening / Johan Schultz -- Application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses / William J. Metzler [and others] -- Target-immobilized NMR screening : validation and extension to membrane proteins / Virginie Früh, Robert J. Heetebrij, and Gregg Siegal -- In situ fragment |