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Immunopharmacology of the gastrointestinal system /

Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of these diseases, including peptic ulcer disease and the gastropathy induced by nonsteroidal an...

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Bibliographic Details
Corporate Authors: Elsevier Science & Technology.
Group Author: Wallace, John L.
Published: Academic Press,
Publisher Address: London ; San Diego :
Publication Dates: 1993.
Literature type: eBook
Language: English
Series: Handbook of immunopharmacology. Systems
Subjects:
Gastrointestinal system > Diseases > Immunological aspects.
Gastrointestinal system.
Adjuvants, Immunologic > therapeutic use.
Gastrointestinal Diseases > drug therapy.
Immunity > drug effects.
Tractus gastro-intestinal > Maladies > Immunologie.
Immunopharmacologie.
Gastrointestinal system > Immunological aspects. > Immunological aspects.
Maagdarmstelsel.
Ziekten.
Immunologie.
Geneesmiddelen.
Humans > Gastrointestinal tract > Diseases
Electronic books.
Online Access: http://www.sciencedirect.com/science/book/9780127328607
Summary: Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of these diseases, including peptic ulcer disease and the gastropathy induced by nonsteroidal anti-inflammatory drugs (NSAIDS). For these reasons, efforts to develop novel therapies for digestive diseases are increasingly focused on the immune system. This volume reviews the immunopharmacology of the gastrointestinal tract at four distinct levels: Immunomodulation at a cellular level Cellular targers for immunomodulating drugs Specific classes of inflammatory mediators Utility and mechanisms of action of glucocorticoids in the treatment of diseases of the gastrointestinal tract.
Carrier Form: 1 online resource (x, 198 pages) : illustrations.
Bibliography: Includes bibliographical references and index.
ISBN: 0127328602
9780127328607
Index Number: RC802
CLC: R57
Contents: 1. Neuromodulation of gastrointestinal immune and inflammatory responses / A. Dean Befus -- 2. Immunomodulation of the gastrointestinal epithelium / Mary H. Perdue and Derek M. McKay -- 3. The immune modulation of intestinal motor function / Stephen M. Collins -- 4. Modulation of neutrophil function as a mode of therapy for gastrointestinal inflammation / Iqbal S. Sandhu and Matthew B. Grisham -- 5. The vascular endothelium in gastrointestinal inflammation / Peter R. Kvietys and D. Neil Granger.
(continued) 6. Modulation of mast cell function in the gastrointestinal tract / Elyse Y. Bissonnette and A. Dean Befus -- 7. Immunopathophysiology of the gastrointestinal tract: role of platelet activating factor / Paul Kubes -- 8. Cytokines / Fabio Cominelli -- 9. Immunopharmacology of eicosanoids in the gastrointestinal tract / John L. Wallace -- 10. Nitric oxide and the gastrointestinal tract / Brendan J.R. Whittle -- 11. Glucocorticoids and gastrointestinal inflammation / Luca Parente and Kenneth G. Mugridge.

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