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Essays in toxicology. Volume 4 /

Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes i...

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Bibliographic Details
Corporate Authors: Elsevier Science & Technology.
Group Author: Hayes, Wayland J., Jr. (Wayland Jackson), 1917-1993 (Editor)
Published: Academic Press,
Publisher Address: New York :
Publication Dates: 1973.
Literature type: eBook
Language: English
Subjects:
Toxicology.
Biochemie.
Milieu.
Toxicologie.
MEDICAL > Pharmacology.
Electronic books.
Online Access: http://www.sciencedirect.com/science/bookseries/00711446/4
Summary: Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of barbiturates. The formation of morphine from heroin and codeine, and the dealkylation to form normorphine and to reduce naloxone to another compound is also considered in the first essay.
Carrier Form: 1 online resource : illustrations
Bibliography: Includes bibliographical references and index.
ISBN: 9781483216447
1483216446
Index Number: RA1218
CLC: R99
Contents: Front Cover; Essays in Toxicology; Copyright Page; Table of Contents; List of Contribotors; Preface; Contents of Previons Volnmes; Chapter 1. Drug Dependence: Whither the Drug?; I. Introduction; II. Mechanism of Tolerance to Barbiturates by Changes in Drug Metabolism; III, Distribution of Barbiturates to the Central Nervous System; IV, Urinary Excretion of Barbiturates; V. Unmasking the Culprit-Heroin; VI. Metabolism of Morphine; VII. Metabolic Transformation of Codeine to Morphine; VIII. Metabolism of Naloxone; IX. Excretion of Narcotics and Metabolites in Urine; X. Transport in Brain.
VIII. Longevity and Median Life-SpanIX. Other Manifestations of Recondite Toxicity; X. Recondite Toxicity of Trace Elements as Expressed by Effects on Reproduction of Rats and Mice; XI. Some Clues to Mechanisms of Toxicity; XII. Production of Chronic Diseases Stimulating Human Disorders; XIII. Recondite Toxicity of Other Metals or Elements in Man; XIV. Innate Toxicity from Water; XV. Summary and Conclusions; References; AUTHOR INDEX; SUBJECT INDEX.

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