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The chemokine system in experimental and clinical hematology

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Bibliographic Details
Corporate Authors: SpringerLink (Online service)
Group Author: Bruserud Øystein.
Published: Springer Verlag,
Publisher Address: Berlin
Publication Dates: c2010.
Literature type: Book
Language: English
Series: Current topics in microbiology and immunology ; 341
Subjects:
Hematology, Experimental.
Blood > Diseases.
Chemokines > Therapeutic use.
Chemotaxis, Leukocyte > physiology.
Graft vs Host Disease > physiopathology.
Leukemia, Myeloid, Acute > physiopathology.
Receptors, Chemokine > therapeutic use.
Stem Cell Transplantation.
Blood > Diseases > Immunological aspects.
Chemokines
Hematology.
Medicine
Electronic books.
Online Access: http://dx.doi.org/10.1007/978-3-642-12639-0
Carrier Form: 1 online resource (xi, 206): ill. (some col.)
ISBN: 9783642126390 (electronic bk.)
3642126391 (electronic bk.)
Index Number: R392
CLC: R392.11
Contents: Includes bibliographical references and index.
Part I. Introduction.-- Chemokine system in experimental and clinical hematology / Oystein Bruserud, Astrid Olsnes Kittang.-- Part II. Experimental hematology.-- Chemokine decoy receptors: strucuture-function and biological properties / Raffaella Bonecchi, Benedetta Savino, Elena M. Borroni, Alberto Mantovani, Massimo Locati.-- Role of chemokines in the biology of natural killer cells / Azzram A. Maghazachi.-- Chemokines in angiogenesis / Anna Dimbert.-- Part III. Immunobiology of allogeneic stem cell transplantation.-- Genetic polymorphisms in the cytokine and chemokine systems: their possible importance in allogeneic stem cell transplantation / Jeurgen Loeffler, Michael Ok, Oliver C. Morton, Markus Mezger, Hermann Einsele.-- Chemokine system: a possible therapeutic target in acute graft versus host disease / Nicolai A. Kittan, Gerhard C. Hildebrandt.-- Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells / Brian G. Engelhardt, James E. Crowe Jr.-- Part IV: Clinical hematology.-- Chemokine network in acute myelogenous leukemia: molecular mechanisms involved in leukemogenesis and therapeutic implications / Astrid Olsnes Kittang, Kimberley Hatfield, Kristoffer Sand, Hakon Reikvam, Oystein Bruserud.-- CXCR4 in clinical hematology / Gary Calandra, Gary Bridger, Simon Fricker.-- Immunobiology of herparin-induced thrombocytopenia / Per Morten Sandset.
The aim of the issue is to describe and explain the importance of the chemokine system in hematology. The chemokine system is probably important for many aspects of normal as well as malignant hematopoiesis. A major focus is the development and treatment of hematologic malignancies, including the immunobiology of stem cell transplantation. The present reviews illustrate that chemokines can be involved in leukemogenesis. The chemokine system is also important both for the crosstalk between malignant cells and their neighbouring nonmalignant stromal cells (including endothelial cells) as well as.

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