Screen LibraryResistance to anti-cancer therapeutics targeting receptor tyrosine kinases and downstream pathways /
This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essenti...
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| Group Author: | ; |
|---|---|
| Published: |
Springer,
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| Publisher Address: | Cham, Switzerland : |
| Publication Dates: | [2018] |
| Literature type: | Book |
| Language: | English |
| Series: |
Resistance to targeted anti-cancer therapeutics,
volume 15 |
| Subjects: | |
| Summary: |
This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance. |
| Carrier Form: | xx, 242 pages : illustrations (some color), portraits ; 24 cm. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9783319679303 3319679309 |
| Index Number: | RC271 |
| CLC: | R730.53 |
| Call Number: | R730.53/R433 |
| Contents: | Resistance of colorectal tumors to anti-EGFR antibodies -- Resistance of lung cancer to kinase inhibitors specific to EGFR or ALK -- Mechanisms of action and resistance of trastuzumab in breast cancer -- Mechanisms of resistance to molecular therapies targeting the HGF/MET axis -- RAF, MEK and ERK inhibitors as anti-cancer drugs: intrinsic and acquired resistance as a major therapeutic challenge -- Mechanisms of resistance to PI3K and AKT inhibitors -- Sensitivity and resistance to BH3 mimetics in cancer therapy -- Resistance mechanisms to cyclin-dependent kinase inhibitors -- Resistance to |