Screen LibraryMovement disorders : genetics and models /
Saved in:
| Corporate Authors: | |
|---|---|
| Group Author: | |
| Published: |
Elsevier/Academic Press,
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| Publisher Address: | London : |
| Publication Dates: |
[2015] ©2015 |
| Literature type: | eBook |
| Language: | English |
| Edition: | Second edition. |
| Subjects: | |
| Online Access: |
http://www.sciencedirect.com/science/book/9780124051959 |
| Item Description: | Preceded by Animal models of movement disorders / edited by Mark LeDoux. c2005. |
| Carrier Form: | 1 online resource (xxiii, 1234 pages) : illustrations (some color) |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9780124055162 0124055168 |
| Index Number: | RC376 |
| CLC: | R742 |
| Contents: |
Section I: Scientific foundations. Taxonomy and clinical features of movement disorders -- Modeling disorders of movement -- New transgenic technologies -- Assessment of movement disorders in rodents -- Drosophila -- Use of Caenorhabditis elegans to model human movement disorders -- Zebrafish -- Techniques for motor assessment in rodents -- Induced pluripotent stem cells (iPSCs) to study and treat movement disorders -- Neurophysiologic assessment of movement disorders in humans -- Neurophysiological and optogenetic assessment of brain networks involved in motor control -- Functional imaging to study movement disorders -- Human and nonhuman primate neurophysiology to understand the pathophysiology of movement disorders -- Section II: Parkinson disease. The phenotypic spectrum of Parkinson disease -- genetics and molecular biology of Parkinson disease -- Genotype-phenotype correlations in Parkinson Disease -- From man to mouse: the MPTP model of Parkinson disease -- Rodent models of autosomal dominant Parkinson disease -- Rodent models of autosomal recessive Parkinson disease -- Drosophila models of Parkinson Disease -- Primate models of complications related to Parkinson disease treatment -- Rodent models of treatment-related complications in Parkinson disease -- Methods and models of the nonmotor symptoms of Parkinson disease -- Section III: Dystonia. Dystonia: phenotypes and genetics -- Murine models of caytaxin deficiency -- Animal models of focal dystonia -- Mouse models of dystonia -- Rodent models of autosomal dominant primary dystonia -- Modeling dystonia-parkinsonism -- Section IV: Huntington disease. Genetics of Huntington disease (HD), HD-like disorders, and other choreiform disorders -- Murine models of HD -- Use of genetically engineered mice to study the biology of huntingtin -- Modeling Huntington disease in yeast and invertebrates -- HDL2 mouse -- Analysis of nonmotor features in murine models of Huntington Disease -- Section V: Tremor. Essential tremor -- Use of the harmaline and [alpha]1 knockout models to identify molecular targets for essential tremor -- Physiological and behavioral assessment of tremor in rodents -- Mouse models of the fragile X tremor/ataxia syndrome (FXTAS) and the fragile X premutation -- Section VI: Myoclonus. Myoclonus: Classification, Clinical Features, and Genetics -- Mouse model of Unverricht-Lundborg disease -- Post-hypoxic myoclonus in rodents -- Generating mouse models of mitochondrial disease -- Secion VII: Tics. Tics and Tourette Syndrome: Phenomenology -- Genetics of Tourette syndrome -- Neural circuit abnormalities in Tourette syndrome -- Animal models of Tourette Syndrome and obsessive-compulsive disorder -- Section VIII: Paroxysmal movement disorders. Paroxysmal Movement Disorders: Clinical and Genetic Features -- Mouse models of PNKD -- Glut1 deficiency (G1D) -- Animal models of episodic ataxia type 1 (EA1) -- Mouse models of episodic ataxia type 2. Section IX: Tauopathies. Tauopathies: Classification, Clinical Features, and Genetics -- Drosophila models of tauopathy -- Tauopathy mouse models -- Tau protein: biology and pathobiology -- Section X: Other Parkinsonian syndromes: NBIA, MSA, PD + spasticity, PD + dystonia. Clinical Phenomenology and genetics of other parkinsonian syndromes associated with either dystonia or spasticity -- Animal models of multiple-system atrophy -- Modeling PKAN in mice and flies -- Mouse models of FA2H deficiency -- Mouse models of neuroaxonal dystrophy caused by PLA2G6 gene mutations -- Section XI: Ataxias. Genetics and Clinical Features of Inherited Ataxias -- Animal models of spinocerebellar ataxia type 1 -- Mouse models of SCA3 and other polyglutamine repeat ataxias -- animal models of Friedreich ataxia -- Ataxia-telangiectasia and the biology of ataxia-telangiectasia mutated (ATM) -- Autosomal recessive ataxias due to defects in DNA repair -- Caenorhabditis elegans models to study the molecular biology of ataxias -- Section XII: Hereditary spastic paraplegia. Hereditary Spastic Paraplegias: Genetics and Clinical Features -- Mouse models of autosomal dominant spastic paraplegia -- Murine models of autosomal recessive hereditary spastic paraplegia -- Modeling hereditary spastic paraplegia (HSP) in zebrafish -- Drosophila models of hereditary spastic paraplegia -- Caenorhabditis elegans models of hereditary spastic paraplegia -- Use of arabidopsis to model hereditary spastic paraplegia and other movement disorders -- Section XIII: Restless legs syndrome. Clinical Phenotype and Genetics of Restless Legs Syndrome -- Combined D3 receptor/iron-deficient mouse model -- Use of Drosophila to study restless legs syndrome -- The A11 lesion/iron deprivation animal model of restless legs syndrome -- Btbd9 knockout mice as a model of restless legs syndrome. |