Screen LibraryDrug safety evaluation : methods and protocols /
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| Group Author: | |
|---|---|
| Published: |
Humana Press,
|
| Publisher Address: | New York, NY : |
| Publication Dates: | [2017] |
| Literature type: | Book |
| Language: | English |
| Edition: | Second edition. |
| Series: |
Methods in molecular biology,
1641 Springer protocols |
| Subjects: | |
| Carrier Form: | xi, 427 pages : illustrations (some color), forms ; 27 cm. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9781493971701 (hardback : alkaline paper) : 1493971700 (hardback : alkaline paper) 9781493971725 (eBook) 1493971727 (eBook) |
| Index Number: | RA1238 |
| CLC: | R927 |
| Call Number: | R927/D794-1/2nd ed. |
| Contents: |
Nonclinical development of combination drugs / Juvenile nonclinical safety studies in support of pediatric drug development / Procedures of necropsy and tissue sampling / Tissue sampling and processing for histopathology evaluation / Principles and methods of immunohistochemistry / Applications of mass spectrometry imaging for safety evaluation / In vivo rat T-lymphocyte Pig-a assay : detection and expansion of cells deficient in the GPI-anchored CD48 surface marker for analysis of mutation in the endogenous Pig-a gene / Detection of in vivo mutation in the Pig-a gene of mouse bone marrow erythroids / Use of bacterial repair endonucleases in the comet assay / Automated patch-clamp methods for the hERG cardiac potassium channel / Impedance measurement in induced pluripotent stem cell-derived cardiomyocytes / Target safety assessment : strategies and resources / NMR and MS methods for metabolomics / Protocols and applications of cellular metabolomics in safety studies using precision-cut tissue slices and carbon 13 NMR / Statistical analysis of auantitative RT-PCR results / Evaluation of mitochondrial respiration in cultured rat hepatocytes / FETAX assay for evaluation of developmental toxicity / Evaluation of embryotoxicity using the Zebrafish model / Absolute quantification of toxicological biomarkers via mass spectrometry / Next-generation sequencing to investigate urinary microRNAs from Macaca fascicularis (cynomolgus monkey) / Quantitative RT-PCR for microRNAs in biofluids / Chromogenic in situ hybridization methods for microRNA biomarker monitoring of drug safety and efficacy / Urine exosome isolation and characterization / |