Screen LibraryPharmacology in clinical practice /
Pharmacology in Clinical Practice describes basic pharmacology, clinical pharmacology, including the pharmacology of important drug groups. The author reviews the general principles of clinical pharmacology including drug actions, absorption, disposition, and excretion. Most drugs are xenobiotics-co...
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| Main Authors: | |
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| Corporate Authors: | |
| Published: |
Heinemann Medical Books,
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| Publisher Address: | London : |
| Publication Dates: | 1980. |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
http://www.sciencedirect.com/science/book/9780433190523 |
| Summary: |
Pharmacology in Clinical Practice describes basic pharmacology, clinical pharmacology, including the pharmacology of important drug groups. The author reviews the general principles of clinical pharmacology including drug actions, absorption, disposition, and excretion. Most drugs are xenobiotics-compounds foreign and harmful to human living tissues. Drugs should be properly metabolized and converted to nontoxic substance before being excreted either through spontaneous changes not mediated by enzymes or through transformation by enzyme systems. The author also discusses pharmacokinetics, incl. |
| Carrier Form: | 1 online resource (vi, 604 pages) : illustrations |
| ISBN: |
9781483192949 1483192946 |
| Index Number: | RM300 |
| CLC: | R96 |
| Contents: |
Front Cover; Pharmacology in Clinical Practice; Copyright Page; Table of Contents ; Preface; Acknowledgements; Part I: General Principles of Clinical Pharmacology; Chapter 1. Drug Actions; Pharmacodynamics; Drug receptors; Dose-effect relationship; The relevance of the mode of action of drugs to clinical pharmacology; Variability in response to drugs; BIBLIOGRAPHY; Chapter 2. Drug Absorption, Disposition and Excretion; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; Chapter 3 Drug Metabolism; Sites of Drug Metabolism; Types of Biotransformation; Factors Affecting Drug Metabolism in Man DiseaseConsequences of Drug Metabolism on Drug Fate; Consequences of Drug Metabolism on Drug Action; Practical Considerations; BIBLIOGRAPHY; Chapter 4. Pharmacokinetics; Drug plasma concentration; Pharmacokinetic models; One compartment open model; Two compartment open model; Clearance; Absorption; First-pass metabolism; Distribution; Elimination; Continuous infusion and multiple doses; The relationship of drug plasma concentration to drug effect; The use of pharmacokinetic data; Practical limitations to the use of pharmacokinetic data; Liver disease The use of drug plasma concentration determinationsPatient compliance; BIBLIOGRAPHY; Chapter 5. Pharmacogenetics; Pharmacokinetic polymorphism; Unimodal frequency distribution; Pharmacodynamic polymorphism; Others; The implications of polymorphisms; BIBLIOGRAPHY; Chapter 6. The Discovery and Introduction of New Drugs; THE EVALUATION OF DRUG EFFECTS; CLINICAL TRIALS; BIBLIOGRAPHY; Chapter 7. Pharmaceutical Aspects of Clinical Pharmacology; Drug formulation; Drug preparation; Presentation; Bioavailability; Bioequivalence; Practical measures; Drug nomenclature; Information on drugs Drug prescribingBIBLIOGRAPHY; Chapter 8. Adverse Reactions to Drugs; MECHANISMS OF ADVERSE DRUG REACTIONS; TYPES OF ADVERSE REACTIONS; BIBLIOGRAPHY; Chapter 9. Drug Interactions; Types of drug interaction; Pharmacokinetic interactions; Drug distribution; Pharmacodynamic Interaction; Consequences of drug interactions; Predicting drug interactions; BIBLIOGRAPHY; Part II: Clinical Pharmacology of Specific Drug Groups; Chapter 10. Cholinergic and Anticholinergic Drugs; CHOLINERGIC DRUGS; ANTICHOLINERGIC DRUGS; BIBLIOGRAPHY; Chapter 11. Adrenergic Receptor Agonists and Antagonists ADRENERGIC RECEPTOR AGONISTSBETA RECEPTOR AGONISTS; INDIRECT-ACTING ADRENERGIC AGENTS; ADRENOCEPTOR ANTAGONISTS (BLOCKERS); BIBLIOGRAPHY; Chapter 12. Anaesthetic Agents; GENERAL ANAESTHETIC AGENTS; INHALATION ANAESTHETICS; THE ETHERS; SATURATED HALOGENATED HYDROCARBONS; UNSATURATED HYDROCARBONS; INORGANIC OXIDE; ALICYCLIC HYDROCARBON; INTRAVENOUS GENERAL ANAESTHETICS; PHENOXYACETIC AMINES; ARYLCYCLOALKYLAMINES; DRUG USAGE IN GENERAL ANAESTHESIA; LOCAL ANAESTHETICS; BIBLIOGRAPHY; Chapter 13. Hypnotics and Minor Tranquillisers; BARBITURATES; BENZODIAZEPINES; MISCELLANEOUS AGENTS; BIBLIOGRAPHY |