Clinical trial design Bayesian and frequentist adaptive methods /
There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. nevertheless, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. This bo...
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Published: |
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Literature type: | eBook |
Language: | English |
Series: |
Wiley series in probability and statistics. |
Subjects: | |
Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/9781118183335 |
Summary: |
There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. nevertheless, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. This book provides an overview of the fundamentals of clinical trials, the key terminologies and concepts, and a brief review and comparison on Bayesian and frequentist estimation and inference procedures. From the practical point of view, this book introduces various statistical methods that are commonly. |
Item Description: | Description based on print version record. |
Carrier Form: | 1 online resource (xvii, 336 pages) : illustrations |
Bibliography: | Includes bibliographical references and indexes. |
ISBN: |
9781118183335 (electronic bk.) 1118183339 (electronic bk.) 9781118183304 (electronic bk.) 1118183304 (electronic bk.) |
Index Number: | R853 |
CLC: | R311 |
Contents: |
Front Matter -- Introduction -- Fundamentals of Clinical Trials -- Frequentist versus Bayesian Statistics -- Phase I Trial Design -- Phase II Trial Design -- Phase III Trial Design -- Adaptive Randomization -- Late-Onset Toxicity -- Drug-Combination Trials -- Targeted Therapy Design -- References -- Author Index -- Subject Index -- Wiley Series in Probability and Statistics --. Fundamentals of clinical trials -- Frequentist versus Bayesian statistics -- Phase I trial design -- Phase II trial design -- Phase III trial design -- Adaptive randomization -- Late onset toxicity -- Drug combination trials -- Targeted therapy design. |