Clinical trial design Bayesian and frequentist adaptive methods /

There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. nevertheless, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. This bo...

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Bibliographic Details
Main Authors: Yin, Guosheng. (Author)
Corporate Authors: Wiley InterScience (Online service)
Published:
Literature type: eBook
Language: English
Series: Wiley series in probability and statistics.
Subjects:
Online Access: http://onlinelibrary.wiley.com/book/10.1002/9781118183335
Summary: There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. nevertheless, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. This book provides an overview of the fundamentals of clinical trials, the key terminologies and concepts, and a brief review and comparison on Bayesian and frequentist estimation and inference procedures. From the practical point of view, this book introduces various statistical methods that are commonly.
Item Description: Description based on print version record.
Carrier Form: 1 online resource (xvii, 336 pages) : illustrations
Bibliography: Includes bibliographical references and indexes.
ISBN: 9781118183335 (electronic bk.)
1118183339 (electronic bk.)
9781118183304 (electronic bk.)
1118183304 (electronic bk.)
Index Number: R853
CLC: R311
Contents: Front Matter -- Introduction -- Fundamentals of Clinical Trials -- Frequentist versus Bayesian Statistics -- Phase I Trial Design -- Phase II Trial Design -- Phase III Trial Design -- Adaptive Randomization -- Late-Onset Toxicity -- Drug-Combination Trials -- Targeted Therapy Design -- References -- Author Index -- Subject Index -- Wiley Series in Probability and Statistics --.
Fundamentals of clinical trials -- Frequentist versus Bayesian statistics -- Phase I trial design -- Phase II trial design -- Phase III trial design -- Adaptive randomization -- Late onset toxicity -- Drug combination trials -- Targeted therapy design.