Screen LibraryThe tumor immunoenvironment /
Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages...
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| Corporate Authors: | |
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| Group Author: | ; ; |
| Published: |
Springer,
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| Publisher Address: | Dordrecht ; New York : |
| Publication Dates: | 2013. |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
http://dx.doi.org/10.1007/978-94-007-6217-6 |
| Summary: |
Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions. |
| Carrier Form: | 1 online resource |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9789400762176 (electronic bk.) 9400762178 (electronic bk.) |
| Index Number: | QR188 |
| CLC: | R730.23 |
| Contents: |
1. Role of the immunological environment in cancer initiation, development and progression -- 2. The metastatic microenvironment -- 3. Tumor infiltration by immune cells: pathologic evaluation and a clinical significance -- 4. Immunologic interpretation of cancer biology: impact on clinical outcome -- 5. Development of antitumor cellular immunity -- 6. The versatile world of inflammatory chemokines in cancer -- 7. Inflammation, tumor progression, and immune suppression -- 8. Pleiotropic and differential functions of IL-1 alpha and IL-1 beta shape the tumor microenvironment and affect the outcome of malignancies -- 9. Impact of obesity and aging on the tumor immuno-environment -- 10. MHC class I antigens and the tumor microenvironment -- 11. Tumor-produced immune regulating factors -- 12. Roles of signaling pathways in cancer cells and immune cells in generation of immunosupressive tumor-associated microenvironments -- 13. T cell mulfunction in the tumor environment -- 14. Signaling of tumor-induced immunosuppression of dendritic cells -- 15. Tumor microenviroment may shape the funtion and phenotype of NK cells through the induction of split anergy and generation of regulatory NK cells -- 16. The roll of myeloid derived supporessor cells in cancer -- 17. Macrophage differentiation and activation states in the tumor microenvironment -- 18. Dendritic cells and cancer: development, dysfunction and therapeutic targets -- 19. The role of tumor associated neutrphils in cancers -- 20. Mast cell modulation of the microenvironment -- 21. Regulatory T cells in patients with cancer -- 22. Tumor-evoked regulatory B cells as important mediators of cancer escape -- 23. Cancer immunotherapy: overview in brief -- 24. Programming of MDSCMDSC: new opportunities for targeted therapy -- 25. Therapeutic targeting regulatory T cells in tumor -- 26. ChemoImmunoModulation: focus on myeloid regulatory cells -- 27. Combining vaccines with therapies that render tumor cells more susceptible t Tumor Microenvironment and Immunoenvironment. The Metastatic Microenvironment / Tumor Infiltration by Immune Cells: Pathologic Evaluation and a Clinical Significance / Immunologic Interpretation of Cancer Biology: Impact on Clinical Outcome / Developmental Characteristics of the Tumor Immunoenvironment. Development of Antitumor Cellular Immunity / The Versatile World of Inflammatory Chemokines in Cancer / Inflammation, Tumor Progression, and Immune Suppression / Pleiotropic and Differential Functions of IL-1 and IL-1 Shape the Tumor Microenvironment and Affect the Outcome of Malignancies / Impact of Obesity and Aging on the Tumor Immuno-Environment / Immune Regulators in the Tumor Immunoenvironment. The Role of Myeloid Derived Suppressor Cells in Cancer / Macrophage Differentiation and Activation States in the Tumor Microenvironment / Dendritic Cells and Cancer: Development, Dysfunction and Therapeutic Targets / The Role of Tumor Associated Neutrophils in Cancer / Mast Cell Modulation of the Tumor Microenvironment / Regulatory T Cells in Patients with Cancer / Tumor-Evoked Regulatory B Cells as Important Mediators of Cancer Escape / Tumor Escape and Cancer Immunotherapy. Cancer Immunotherapy: Overview in Brief / Programming of MDSC: New Opportunities for Targeted Therapy / Therapeutic Targeting Regulatory T Cells in Tumor / ChemoImmunoModulation: Focus on Myeloid Regulatory Cells / Combining Vaccines with Therapies that Render Tumor Cells more Susceptible to Immune Mediated Killing / Prophylactic Cancer Vaccines / Analyzing Immune Responses in Cancer. Approaches to Immunologic Monitoring of Clinical Trials / Evaluation of the Tumor Immunoenvironment in Clinical Trials / Analysis of Myeloid-Derived Suppressor Cells in Patients with Cancer / When Results of T cell Immune Monitoring Match/Do Not Match Clinical Outcomes of Tumor Vaccine Trials: What More Could and Should We Measure? / |