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Mass spectrometry in drug metabolism and disposition basic principles and applications /

"This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to...

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Bibliographic Details
Group Author: Lee, Mike S., 1960; Zhu, Mingshe
Published:
Literature type: Electronic eBook
Language: English
Series: Wiley series on pharmaceutical science and biotechnology: practices, applications and methods
Subjects:
Drugs > Metabolism > Analysis
Metabolites > Spectra
Mass spectrometry
Pharmacy
Medicine
MEDICAL > Pharmacology
Pharmaceutical Preparations > metabolism
Biopharmaceutics > methods
Drug Design
Mass Spectrometry > methods
Pharmacokinetics
Electronic books
Online Access: http://onlinelibrary.wiley.com/book/10.1002/9780470929278
Summary: "This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sect
Carrier Form: 1 online resource.
Bibliography: Includes bibliographical references and index.
ISBN: 9780470929278 (electronic bk.)
0470929278 (electronic bk.)
9780470929261 (electronic bk.)
047092926X (electronic bk.)
Index Number: RM301
CLC: R969.1
Contents: Frontmatter -- Basic Concepts of Drug Metabolism and Disposition. Progression of Drug Metabolism / Ronald E White -- Common Biotransformation Reactions / Bo Wen, Sidney D Nelson -- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry / Amit S Kalgutkar -- Drug-Metabolizing Enzymes, Transporters, and Drug-Drug Interactions / Steven W Louie, Magang Shou -- Experimental Models of Drug Metabolism and Disposition / Gang Luo, Chuang Lu, Xinxin Ding, Donglu Zhang -- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics in Drug Discovery / Takehito Yamamoto,
(Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition -- The Progression of Drug Metabolism -- Common Biotransformation Reactions -- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry -- Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions -- Experimental Models of Drug Metabolism and Disposition -- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics -- Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes -- Part II Mass Spectrometry in Drug Metabolism: Principles a

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