Screen LibraryTarget discovery and validation：reviews and protocols.. V. 1,, Emerging strategies for targets and biomarker discovery
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| Group Author: | |
|---|---|
| Published: |
Humana Press,
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| Publisher Address: | Totowa, N.J. |
| Publication Dates: | c2007. |
| Literature type: | Book |
| Language: | English |
| Series: |
Methods in molecular biology ; 360-361 |
| Subjects: | |
| Carrier Form: | xii, 354 p: ill. ; 24 cm. |
| ISBN: |
1588296563 (v. 1 : alk. paper) 9781588296566 (v. 1 : alk. paper) 9781588296566 1597451657 (e-ISBN) 9781597451659 (e-ISBN) |
| Index Number: | R730 |
| CLC: | R730 |
| Call Number: | R730/T185/V.1 |
| Contents: |
Includes bibliographical references and indexes. v. 1. Emerging strategies for targets and biomarker discovery -- v. 2. Emerging molecular targets and treatment options. Contents of Volume 1 -- Main Approaches to Target Discovery and Validation / Mouldy Sioud -- Bioinformatics Approaches to Cancer Gene Discovery / Ramaswamy Narayanan -- Analysis of Gene Networks for Drug Target Discovery and Validation / Seiya Imoto ... [et al.] -- Target Discovery and Validation in Pancreatic Cancer / Robert M. Beaty ... [et al.] -- Molecular Classification of Breast Tumors: Toward Improved Diagnostics and Treatments / Therese Sørlie -- Discovery of Differentially Expressed Genes: Technical Considerations / Øystein Røsok and Mouldy Sioud -- Genome-Wide Screening by Using Small-Interfering RNA-Expression Libraries / Sahohime Matsumoto, Makoto Miyagishi, and Kazunari Taira -- Hammerhead Ribozyme-Based Target Discovery / Masayuki Sano and Kazunari Taira -- Production of siRNA and cDNA-Transfected Cell Arrays on Noncoated Chambered Coverglass for High-Content Screening Microscopy in Living Cells / Holger Erfle and Rainer Pepperkok -- Transgenic Animal Models in Biomedical Research / Louis-Marie Houdebine -- Keratin Trangenic and Knockout Mice: Functional Analysis and Validation of Disease-Causing Mutations / Preethi Vijayaraj, Goran Söhl, and Thomas M. Magin -- The HUVEC/Matrigel Assay: An In Vivo Assay of Human Angiogenesis Suitable for Drug Validation / Dag K. Skovseth, Axel M. Küchler, and Guttorm Haraldsen -- A Murine Model for Studying Hematopoiesis and Immunity in Heart Failure / Per Ole Iversen and Dag R. Sørensen -- An Overview of the Immune System and Technical Advances in Tumor Antigen Discovery and Validation / Mouldy Sioud -- Potential Target Antigens for Immunotherapy Identified by Serological Expression Cloning (SEREX) / Dirk Jäger -- Identification of Tumor Antigens by Using Proteomics / Francois Le Naour -- Protein Arrays: A Versatile Toolbox for Target Identification and Monitoring of Patient Immune Responses / Lina Cekaite, Eivind Hovig, and Mouldy Sioud -- Index. Contents of Volume 2 -- Druggable Signaling Proteins / Mouldy Sioud and Marianne Leirdal -- DNA Methylation and Histone Modifications in Patients with Cancer: Potential Prognostic and Therapeutic Targets / Michel Herranz and Manel Esteller -- Wnt Signaling as a Therapeutic Target for Cancer / Andreas Herbst and Frank Thomas Kolligs -- The NG2/HMP Proteoglycan as a Cancer Therapeutic Target / Martha Chekenya and Heike Immervoll -- Heterotrimeric G Proteins and Disease / Øyvind Melien -- High-Mobility Group Box-1 Isoforms as Potential Therapeutic Targets in Sepsis / William Parrish and Luis Ulloa -- Antisense Oligonucleotides: Target Validation and Development of Systemically Delivered Therapeutic Nanoparticles / Chuanbo Zhang, Jim Pei, Deepak Kumar, Isamu Sakabe, Howard E. Boudreau, Prafulla C. Gokhale, and Usha N. Kasid -- Nucleic Acid-Based Aptamers as Promising Therapeutics in Neoplastic Diseases / Laura Cerchia and Vittorio de Franciscis -- Guidelines for the Selection of Effective Short-Interfering RNA Sequences for Functional Genomics / Kumiko Ui-Tei, Yuki Naito, and Kaoru Saigo -- Suppression of Apoptosis in the Liver by Systemic and Local Delivery of Small-Interfering RNA / Lars Zender and Stefan Kubicka -- Target Validation Using RNA Interference in Solid Tumors / Seyedhossein Aharinejad, Mouldy Sioud, Trevor Lucas, and Dietmar Abraham -- Validation of Telomerase and Survivin as Anticancer Therapeutic Targets Using Ribozymes and Small-Interfering RNAs / Nadia Zaffaroni, Marzia Pennati, and Marco Folini -- Collagen-Induced Arthritis in Mice: A Major Role for Tumor Necrosis Factor-alpha / Richard O. Williams -- Novel Opportunities for Therapeutic Targeting in Systemic Autoimmune Diseases / Meryem Quarzane and Moncef Zouali -- Considerations for Target Validation and Industrial Approaches / Carlos R. Plata-Salamán and Sergey E. Ilyin -- Regulatory RNAs: Future Perspectives in Diagnosis, Prognosis, and Individualized Therapy / Marjorie P. Perron, Vincent Boissonneault, Lise-Andrée Gobeil, Dominique L. Ouellet, and Patrick Provost -- Treatment Options and Individualized Medicine / Mouldy Sioud and Øyvind Melien -- Index. |