Screen LibraryGlioma signaling /
Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumors, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and...
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| Corporate Authors: | |
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| Group Author: | |
| Published: |
Springer,
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| Publisher Address: | Dordrecht ; New York : |
| Publication Dates: | 2013. |
| Literature type: | eBook |
| Language: | English |
| Series: |
Advances in experimental medicine and biology,
986 |
| Subjects: | |
| Online Access: |
http://dx.doi.org/10.1007/978-94-007-4719-7 |
| Summary: |
Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumors, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. Glioma Signaling is a text reference on cellular signaling processes regulating gliomas physiology and invasiveness. The first half of the book is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides. The remaining chapters deal with the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration, cellular growth, progression and invasion, as well as presents perspectives concerning potential targets for glioma therapy. |
| Carrier Form: | 1 online resource. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9789400747197 (electronic bk.) 9400747195 (electronic bk.) |
| Index Number: | RC280 |
| CLC: | R739.41 |
| Contents: |
Introduction to Purinergic Signalling in the Brain / Adenosine Signaling in Glioma Cells / Cross-Talk in Nucleotide Signaling in Glioma C6 Cells / Calcium Signaling in Glioma Cells - The Role of Nucleotide Receptors / Purinergic Signaling in Glioma Progression / Cytoskeleton and Nucleotide Signaling in Glioma C6 Cells / Signaling Determinants of Glioma Cell Invasion / Receptor Tyrosine Kinases: Principles and Functions in Glioma Invasion / TGF Beta Signaling and Its Role in Glioma Pathogenesis / STAT Signaling in Glioma Cells / Cannabinoid Signaling in Glioma Cells / |