Screen LibraryDisease gene identification : methods and protocols /
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| Group Author: | |
|---|---|
| Published: |
Humana Press,
|
| Publisher Address: | New York, NY : |
| Publication Dates: | [2018] |
| Literature type: | Book |
| Language: | English |
| Edition: | Second edition. |
| Series: |
Methods in molecular biology,
1706 Springer protocols, |
| Subjects: | |
| Carrier Form: | x, 400 pages : illustrations (some color) ; 26 cm. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9781493974702 149397470X |
| Index Number: | RB155 |
| CLC: | R394 |
| Call Number: | R394/D611/2nd ed. |
| Contents: |
Identification of disease susceptibility alleles in the next generation sequencing era / Induced pluripotent stem cells in disease modeling and gene identification / Development of targeted therapies based on gene modification / What can we learn about human disease from the nematode C. elegans / Microbiome sequencing methods for studying human diseases / Emerging role of long noncoding RNAs in human disease / Identification of disease-related genes using a genome-wide association study approach / Whole genome library construction for next generation sequencing / Whole exome library construction for next generation sequencing / Optimized methodology for the generation of RNA-sequencing libraries from low-input starting material : enabling analysis of specialized cell types and clinical samples / Using fluidigm C1 to generate single-cell full-length cDNA libraries for mRNA sequencing / MiSeq : a next generation sequencing platform for genomic analysis / Methods for CpG methylation array profiling via bisulfite conversion / miRNA quantification method using quantitative polymerase chain reaction in conjunction with Cq method / Primary airway epithelial cell gene editing using CRISPR-Cas9 / RNA interference to knock down gene expression / Using luciferase reporter assays to identify functional variants at disease-associated loci / Physiologic interpretation of GWAS signals for type 2 diabetes / Identification of Genes for Hereditary Hemochromatosis / Identification of driver mutations in rare cancers : the role of SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) / Rise and fall and rise of linkage analysis as a technique for finding and characterizing inherited influences on disease expression / |