Screen LibraryDetection of drugs and their metabolites in oral fluid /
Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. The authors summarize the state of the science, including its strengths, weaknesses, unmet methodological nee...
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| Main Authors: | |
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| Corporate Authors: | |
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| Published: |
Elsevier,
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| Publisher Address: | Amsterdam, Netherlands : |
| Publication Dates: | [2018] |
| Literature type: | eBook |
| Language: | English |
| Series: |
Emerging issues in analytical chemistry
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| Subjects: | |
| Online Access: |
https://www.sciencedirect.com/science/book/9780128145951 |
| Summary: |
Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. The authors summarize the state of the science, including its strengths, weaknesses, unmet methodological needs, and cutting-edge trends. This volume covers the salient aspects of oral fluid drug testing, including specimen collection and handling, initial testing, point of collection testing (POCT), specimen validity testing (SVT), and confirmatory and proficiency testing. Analytes discussed include amphetamines, cannabinoids, cocaine, opiates, phencyclidine, cannabimimetics, and miscellaneous drugs. This practical guide helps users turn knowledge into practice, moving logically from an outline of the problem, to the evaluation of the appropriateness of oral fluid as a test medium, and finally to a consideration of detection methods and their validation and employment. |
| Carrier Form: | 1 online resource (125 pages) : illustrations (some color). |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9780128145968 012814596X |
| Index Number: | RB52 |
| CLC: | R781-532 |
| Contents: |
Front Cover; Detection of Drugs and Their Metabolites in Oral Fluid; Copyright Page; Dedication; Contents; Preface; Acknowledgments; 1 Introduction; General; Disease States That May Influence Salivary Function; The Influence of Drugs on Salivary Function; References; 2 Oral Fluid Pharmacokinetics; Introduction; Ethanol; Ethyl Alcohol, a#x80;#x9C;Alcohol a#x80;#x9D;; Cannabinoids; Cocaine; Amphetamines; Methamphetamine; Methylenedioxymethamphetamine; Opiates; Codeine, Morphine, and Diacetylmorphine; Hydrocodone; Oxycodone; Benzodiazepines; Other Drugs; Phencyclidine; Methadone; Fentanyl; Nicotine. New Psychoactive SubstancesReferences; 3 Collection of Oral Fluid; Introduction; Neat Oral Fluid; Advantages; Disadvantages; Saliva Collection System; Pad, No Buffer; Advantages; Disadvantages; Pad and Buffer; Advantages; Disadvantages; Summary; References; 4 Point of Collection Testing; Introduction; Evaluation; Specific Applications; Driving Under the Influence of Drugs; Clinical Applications; References; 5 Initial Testing; Introduction; Sensitivity; Cross-Reactivity; Chromatography a#x80;#x93;Mass Spectrometry; Conclusions; References; 6 Specimen Validity Testing; Introduction; Oral Fluid SVT. ConclusionReferences; 7 Confirmatory Testing; Introduction; Separation; Method Validation; Sensitivity; Major Drug Classes; Amphetamines; Cocaine; Cannabis; Benzodiazepines; Opioids; Phencyclidine; Novel Psychoactive Substances; Derivatization in LC-MS; Chiral Separation of Amphetamine and Methamphetamine; Improved Sensitivity for THC-COOH in Oral Fluid; Improved Sensitivity for 11-OH-THC in Oral Fluid; Summary; References; 8 Interlaboratory Comparison; Introduction; Commercial Controls; Blind Controls; Internally Submitted; Externally Submitted; Proficiency Testing. SAMHSA Oral Fluid Pilot PT ProgramCollege of American Pathologists; RTI Proficiency Testing Program for Alcohol and Drugs in Oral Fluid; Performance Testing; Summary; References; 9 Individual Analytes, Specimen Handling, Stability, and Other Issues; Introduction; Oral Fluid; I#x94;9-Tetrahydrocannabinol; Cocaine; Amphetamines; Opiates; Benzodiazepines; References; 10 Concluding Remarks; Strengths of Oral Fluid as a Test Matrix; Weaknesses of Oral Fluid as a Test Matrix; Methodological Needs; Cutting-Edge Trends; Summary; Index; Back Cover. |