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Biosimulation in drug development

This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms. Following an introduction to the role of biosimulat...

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Bibliographic Details
Corporate Authors: Wiley InterScience Online service
Group Author: Bertau, Martin; Mosekilde, Erik; Westerhoff, Hans V
Published:
Literature type: Electronic eBook
Language: English
Subjects:
Drug development > Simulation methods
MEDICAL > Chemotherapy
Drug Design
Computer simulation
Models, Theoretical
Electronic books
Online Access: http://onlinelibrary.wiley.com/book/10.1002/9783527622672
Summary: This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms. Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial drug
Carrier Form: xxviii, 512 p. : ill. (some col.) ; 25 cm.
Bibliography: Includes bibliographical references and index.
ISBN: 9783527622672
3527622675
9783527622689 (electronic bk.)
3527622683 (electronic bk.)
1281946982
9781281946980
Index Number: RM301
CLC: R914
Contents: Cover -- Contents -- Preface -- List of Contributors -- Part I Introduction -- 1 Simulation in Clinical Drug Development -- 1.1 Introduction -- 1.2 Models for Simulations -- 1.3 Simulations in Clinical Drug Development: Practical Examples -- 1.4 Conclusions -- 2 Modeling of Complex Biomedical Systems -- 2.1 Introduction -- 2.2 Pulsatile Secretion of Insulin -- 2.3 Subcutaneous Absorption of Insulin -- 2.4 Bursting Pancreatic 946;-Cells -- 2.5 Conclusions -- 3 Biosimulation of Drug Metabolism -- 3.1 Introduction -- 3.2 Experimental Approaches -- 3.3 The Biosimulation Approach -- 3.4 Ethical I

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