Screen LibraryBiometals in neurodegenerative diseases : mechanisms and therapeutics /
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| Corporate Authors: | |
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| Group Author: | ; ; ; |
| Published: |
Academic Press is an imprint of Elsevier,
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| Publisher Address: | London, United Kingdom : |
| Publication Dates: | 2017. |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
https://www.sciencedirect.com/science/book/9780128045626 |
| Item Description: | Includes index. |
| Carrier Form: | 1 online resource |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
9780128045633 0128045639 |
| Index Number: | QP532 |
| CLC: | Q58 |
| Contents: |
Cover; Title page; Copyright page; Contents; Contributors; Preface; Chapter 1 -- Biometals and Alzheimer's Disease; Introduction; The Role of Copper in AD; The Role of Zinc in AD; The Role of Iron in AD; Therapeutic Targeting of Biometals in AD; Conclusions; References; Chapter 2 -- Copper in Alzheimer's Disease; Introduction; The Physiology of Copper; Copper Absorption and Distribution; Copper in the Liver; Copper's Path From General Circulation to the Brain; The Key Role of Ceruloplasmin; Copper Toxicity; The Role of Copper in Alzheimer's Disease; Genetics of Copper and AD. The AD Copper SubtypeConclusions; References; Chapter 3 -- The Role of Selenium in Neurodegenerative Diseases; Introduction; Selenoproteins and the Selenoproteome; Selenium and Alzheimer's Disease; Parkinson's Disease; Other Neurodegenerative Diseases; Conclusions; References; Chapter 4 -- Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?; Iron; Hemochromatosis; Discovery; Types; HFE; Structure; Function; Polymorphisms; Macrophages; Macrophage and Iron Metabolism; Macrophage Polarization; Macrophages and HFE; HFE and Neurodegenerative Diseases. Alzheimer's DiseaseAmyotrophic Lateral Sclerosis; Parkinson's Disease; HFE and Cancer; HFE Animal Models; Conclusions; References; Chapter 5 -- Chemical Elements and Oxidative Status in Neuroinflammation; Introduction; Metal-Induced Neurotoxicity and Multiple Sclerosis; Metals and Oxidative Status in Multiple Sclerosis; Metals and Oxidative Status in Clinically Isolated Syndromes; Conclusions; References; Chapter 6 -- Metals and Neuroinflammation; Introduction; Mechanisms by Which Metal Elements Can Incite Immune Activity; Metals as Haptens; Metal Elements with Valence Instability; Copper (Cu). Iron (Fe)Manganese; Metals Attaching to Sulfhydryl Residues; Lead (Pb); Mercury (Hg); Metals Associated with Particulate and Colloidal Materials; Aluminum (Al); Titanium, Silver and Gold (Ti, Ag, Au); Metals Which Lead to Oxidative Stress and Inflammation by Means that are not yet Understood; The Relation Between Reactive Oxygen and Nitrogen Species and Inflammation; Conclusions; References; Chapter 7 -- Metals and Prions: Twenty Years of Mining the Awe; Prion Diseases; Prion Protein; Prion Protein Function; Copper and PrP; Zinc and PrP; Iron and PrP; Manganese and PrP; Metals in Prion Disease. Chelation Therapy and Prion DiseaseConclusions; References; Chapter 8 -- Manganese and Neurodegeneration; Background; Mn Essentiality and Metabolic Functions; Mn Biokinetics and Homeostatic Control; Routes and Sources of Mn Exposure; Absorption of Airborne Mn; Parenteral Exposure to Mn; Oral Absorption of Mn From Food and Water; Mn Biodistribution and Elimination; Biokinetics of Mn in Brain; Mn Transport Into Brain; Regional Delivery of Mn in the Brain; Mn Elimination From Brain Compartment; Subcellular Distribution of Mn in Brain; Homeostatic Control of Mn. |