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Novel immune potentiators and delivery technologies for next generation vaccines /

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and f...

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Bibliographic Details
Corporate Authors: SpringerLink (Online service)
Group Author: Manmohan Singh
Published: Springer,
Publisher Address: New York :
Publication Dates: 2013.
Literature type: eBook
Language: English
Subjects:
Vaccines > immunology.
Adjuvants, Immunologic.
Drug delivery systems.
Immunotherapy.
Vaccines.
Vaccines > Biotechnology.
Immunology.
Medicine.
Microbiology.
Pharmaceutical technology.
Biomedicine.
Medical Microbiology.
Electronic books.
Online Access: http://dx.doi.org/10.1007/978-1-4614-5380-2
Summary: Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations--many of which will be nanoparticulates--can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.
Item Description: Includes index.
Carrier Form: 1 online resource
ISBN: 9781461453802 (electronic bk.)
1461453801 (electronic bk.)
Index Number: QR189
CLC: R979.5
Contents: Novel Immune Potentiators and delivery systems for enhancing vaccine potency --
TLR7/8 Agonists as Vaccine Adjuvants /
Preclinical and Clinical Development of Synthetic iNKT-Cell Glycolipid Agonists as Vaccine Adjuvants /
Mucosal Vaccination: Opportunities and Challenges /
Oral Vaccination: Attenuated and Gene-Based /
Design and Development of next generation vaccines --
Development of Biophysical Assays to Better Understand Adjuvanted Vaccine Formulation Potency and Stability /
High Throughput Screening for Stabilizers of Vaccine Antigens /
Exploring Novel Analytical Tools to Improve Characterization of Vaccine Formulations /
Immunobioengineering Approaches Towards Combinatorial Delivery of Immune-Modulators and Antigens /
Novel Delivery Technologies for vaccines --
Current Status of Electroporation Technologies for Vaccine Delivery /
Microneedles for Intradermal Vaccination: Immunopotentiation and Formulation Aspects /
MicroCor?Transdermal Delivery System: A Safe, Efficient, and Convenient Transdermal System for Vaccine Administration /
Mimopath[TM]-Based Vaccine Delivery /
Novel Particulate delivery systems for vaccines and adjuvants --
NanoBio[TM] Nanoemulsion for Mucosal Vaccine Delivery /
Influenza Virosomes as Antigen Delivery System /
Matrix M Adjuvant Technology /
Safety assessment of next generation vaccines --
Strategies for the Nonclin

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