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Discovery and development of neuroprotective agents from natural products : natural product drug discovery /

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction o...

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Bibliographic Details
Corporate Authors: Elsevier Science & Technology.
Group Author: Brahmachari, Goutam
Published: Elsevier,
Publisher Address: [Place of publication not identified] :
Publication Dates: 2017.
Literature type: eBook
Language: English
Subjects:
Hypoglycemic agents.
Neuroprotective Agents.
HEALTH & FITNESS > General. > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Electronic books.
Online Access: https://www.sciencedirect.com/science/book/9780128095935
Summary: Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer's disease, Parkinson's disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs.
Carrier Form: 1 online resource (480 pages)
Bibliography: Includes bibliographical references and index.
ISBN: 9780128097694
0128097698
Index Number: RC661
CLC: R741.01-53
Contents: Front Cover; Discovery and Development ofNeuroprotective Agents fromNatural Products: Natural Product Drug Discovery; Discovery and Development of Neuroprotective Agents from Natural Products: Natural Product Drug Discovery; Copyright; Dedication; Contents; List of Contributors; Editor Biography; Foreword; NATURAL PRODUCT DRUG DISCOVERY: THE ROAD AHEAD; Preface; 1 -- Discovery and Development of Neuroprotective Agents From Natural Products: An Overview; 1. INTRODUCTION; 2. AN OVERVIEW OF THE BOOK; 2.1 Chapter 2; 2.2 Chapter 3; 2.3 Chapter 4; 2.4 Chapter 5; 2.5 Chapter 6; 2.6 Chapter 7.
2.7 Chapter 82.8 Chapter 9; 2.9 Chapter 10; 2.10 Chapter 11; 2.11 Chapter 12; 3. CONCLUDING REMARKS; 2 -- Natural Phytoestrogens: A Class of Promising Neuroprotective Agents for Parkinson Disease; 1. INTRODUCTION ON PARKINSON DISEASE; 1.1 Parkinson Disease and Gonadal Hormones; 1.2 Animal Models of Parkinson Disease: Sex Difference and Estrogen Effects; 2. PHYTOESTROGENS; 3. MECHANISMS OF ACTION OF ESTROGENS AND PHYTOESTROGENS IN NEUROPROTECTION OF DOPAMINE NEURONS; 3.1 Brain Estrogen Receptor; 3.2 Estrogenic Activity of Phytoestrogens.
3.3 Neurotrophic Signaling Pathways Induced by Estrogens and Phytoestrogens3.4 Antioxidant and Antiinflammatory Activities of Estrogens and Phytoestrogens; 4. PHYTOESTROGENS AND PARKINSON DISEASE; 4.1 Neuroprotective Effects of Flavonoids in Parkinson Disease; 4.1.1 Neuroprotective Effects of Flavanols in Parkinson Disease; 4.1.2 Neuroprotective Effects of Flavonols in Parkinson Disease; 4.1.2.1 Quercetin; 4.1.2.2 Myricitrin; 4.1.2.3 Kaempferol; 4.1.2.4 Bu-7; 4.1.2.5 Morin; 4.1.2.6 Hydroxysafflor Yellow A; 4.1.2.7 Fustin; 4.1.3 Neuroprotective Effects of Flavones in Parkinson Disease.
4.1.3.1 Baicalein4.1.3.2 7,8-Dihydroxyflavone; 4.1.3.3 Apigenin and Luteolin; 4.1.3.4 Nobiletin; 4.1.3.5 Tangeretin; 4.1.3.6 Chrysin; 4.1.3.7 Acacetin; 4.1.3.8 Moracenin D; 4.1.4 Neuroprotective Effects of Isoflavones in Parkinson Disease; 4.1.4.1 Genistein and Daidzein; 4.1.4.2 Puerarin; 4.1.4.3 Biochanin A; 4.1.5 Neuroprotective Effects of Flavanones in Parkinson Disease; 4.1.5.1 Naringenin and Naringin; 4.1.5.2 Hesperidin; 4.1.5.3 Pinocembrin; 4.1.6 Neuroprotective Effects of Tanshinone I in Parkinson Disease; 5. SOURCES OF FURTHER INFORMATION; 6. CONCLUDING REMARKS; LIST OF ABBREVIATIONS.
ACKNOWLEDGMENTSREFERENCES; 3 -- Natural Compounds and Their Derivatives as Multifunctional Agents for the Treatment of Alzheimer Disease; 1. INTRODUCTION; 2. CURRENT TREATMENT OF ALZHEIMER DISEASE; 3. PLANT PRODUCTS WITH ANTI-ALZHEIMER POTENTIAL; 3.1 Galanthus and Narcissus Species (Family: Amaryllidaceae); 3.2 Berberis Species (Family: Berberidaceae); 3.3 Cistus Species (Family: Cistaceae); 3.4 Huperzia serrata (Family: Huperziaceae); 3.5 Crocus sativus L. (Family: Iridaceae); 3.6 Lamiaceae Plants; 3.6.1 Melissa officinalis L; 3.6.2 Origanum Species; 3.6.3 Rosmarinus officinalis L.

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