Screen LibraryEnvironmental epigenomics in health and disease epigenetics and disease origins /
Exposure to environmental toxicants is associated with changes in DNA methylation and gene expression profiles that together can contribute to increased disease susceptibility. The chapters in this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, address a w...
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| Group Author: | ; |
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| Literature type: | Electronic eBook |
| Language: | English |
| Series: |
Epigenetics and human health
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| Online Access: |
http://dx.doi.org/10.1007/978-3-642-23380-7 |
| Summary: |
Exposure to environmental toxicants is associated with changes in DNA methylation and gene expression profiles that together can contribute to increased disease susceptibility. The chapters in this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, address a wide range of environmental exposures, such as airborne particulates, cocaine, radiation, tobacco smoke, and xenoestrogens. Particular emphasis is placed on the consequences of environmental exposures during development on epigenetic reprogramming that influences adult disease pathogenesis. Health outcomes associated with these exposures include autoimmune disorders, neurodevelopmental disorders, and cancer. Importantly, dietary supplements and drugs can modify the epigenetic effects induced by these agents, thereby reducing their toxicological impact. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic processes and developmental programming. |
| Item Description: | Includes index. |
| Carrier Form: | 1 online resource (xv, 302 p.) : ill. (some col.). |
| ISBN: |
9783642233807 (electronic bk.) 3642233805 (electronic bk.) |
| Index Number: | RA651 |
| CLC: | R12 |
| Contents: |
Fetal Origins of Adult Disease Susceptibility -- Epigenetics: How Genes and Environment Interact / Developmental Epigenomics and Metabolic Disease / Sculpting Our Future: Environmental Nudging of the Imprintome / Epigenetics and Environmental Exposures -- Complex Phenotypes: Epigenetic Manifestation of Environmental Exposures / Epigenetic Effects of Ionizing Radiation / The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE-1 Retrotransposons by Environmental Injury / Epigenetics, Gene Regulation, and Stem Cells -- Environmental Impact on Epigenetic Histone Language / Chromatin Structure and Gene Expression: Function Follows Form / Epigenetics of Pluripotency / Epigenetic Transgenerational Inheritance -- Transgenerational Epigenetic Inheritance in Drosophila / Environmental Epigenetics and Epigenetic Transgenerational Inheritance / The Nature of Human Transgenerational Responses / |