Screen LibraryDrug discovery handbook
The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs.This comprehensive, practical guide presents an explanation of the...
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| Published: |
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| Literature type: | Electronic eBook |
| Language: | English |
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| Online Access: |
http://onlinelibrary.wiley.com/book/10.1002/0471728780 |
| Summary: |
The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs.This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Spec |
| Carrier Form: | 1 online resource (xix, 1471 p.) : ill. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: |
0471728772 (electronic bk.) 9780471728771 (electronic bk.) 0471728780 (electronic bk.) 9780471728788 (electronic bk.) |
| Index Number: | RM301 |
| CLC: | R914.2-62 |
| Contents: |
Drug discovery in the 21st century -- Natural products / Cancer cell proteomics using molecular aptamers / Molecular similarity methods and QSAR models as tools for virtual screening / Systems biology : applications in drug discovery / High throughput flow cytometry / Combining NMR spectral information with associated structural features to form computationally nonintensive, rugged, and objective models of biological activity / Age of regulation / Simultaneous screening of multiple cell lines using the CellCard system / Protein X-ray crystallography in drug discovery / Biological and chemistry assays available during drug discovery and developability assessment / Strategies and methods in monitoring and targeting protein-protein interactions / High-throughput screening : evolution of technology and methods -- Martyn N. Banks ... [et al.] -- Metal-enhanced fl Methods for the design and analysis of replicate-experiment studies to establish assay reproducibility and the equivalence of two potency assays / Coupled luminescent methods in drug discovery : 3-minute assays for cytotoxicity and phosphatase activity / Design and pharmaceutical applications of prodrugs / GABA and glutamate receptor ligands and their therapeutic potential in CNS disorders / Cardiac sarcolemmal ATP-sensitive potassium channel antagoni Factors influencing the efficacy of mediator-specific anti-inflammatory, glucocorticoid, and anticoagulant therapies for sepsis / Combinatorial chemistry in the drug discovery process / Herbal medicines and animal models of gastrointestinal diseases / Endocrine and metabolic agents / Respiratory viruses / Strategies in the design of antiviral drugs / Protein kinase inhibitors in drug disc |