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Mammalian alkaline phosphatases from biology to applications in medicine and biotechnology.

A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: The structure, regulation and expression of the AP genes; The three-dimensional structure of APs and mutagenesis work that further defined the str...

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Bibliographic Details
Main Authors: Millán, José Luis.
Corporate Authors: John Wiley & Sons.
Published:
Literature type: Electronic eBook
Language: English
Subjects:
Alkaline phosphatase.
Alkaline Phosphatase > genetics.
Alkaline Phosphatase > therapeutic use.
Mammals > genetics.
Models, Animal.
Models, Genetic.
SCIENCE > Biochemistry. > Biochemistry.
Electronic books.
Online Access: http://onlinelibrary.wiley.com/book/10.1002/3527608060
Summary: A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: The structure, regulation and expression of the AP genes; The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes; The phenotypic abnormalities of the different AP knockout mice; Our current understanding of the in vivo role of the AP isozymes. The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzym.
Carrier Form: 1 online resource (xv, 322 pages)
Bibliography: Includes bibliographical references and index.
ISBN: 3527310797
9783527310791
3527608060
9783527608065
9783527607471
3527607471
Index Number: QP609
CLC: Q55
Contents: Preface -- Abbreviations -- Glossary -- Introduction -- pt. I. Gene and protein structure ; 1. Gene structures ; 2. Developmental expression ; 3. Gene regulation ; 4. Protein structure and functional domains ; 5. Enzymatic properties ; 6. Epitope maps -- pt. II. In vivo functions ; 7. The in vivo role of TNAP ; 8. Knockout mouse models -- pt. III. AP expression in health and disease ; 9. APs as physiological and disease markers ; 10. Neoplastic expression of PLAP, GCAP, IAP (Regan, Nagao, Kasahara) and TNAP isozymes -- pt. IV. Uses of APs in industry and biotechnology ; 11. Applications of recombinan APs ; 12. Use of APs in prodrug converting strategies ; 13. APs as therapeutic agents ; 14. APs in the food industry ; 15. Veterinary uses of AP determinations ; 16. Methodologies.

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