Screen LibraryDNA topology
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| Main Authors: | |
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| Group Author: | |
| Published: |
IRL Press at Oxford University Press,
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| Publisher Address: | Oxford New York |
| Publication Dates: | 2005. |
| Literature type: | Book |
| Language: | English |
| Series: |
In focus |
| Subjects: | |
| Carrier Form: | xvii, 198 p.: ill. (some col.) ; 23 cm. |
| ISBN: | 019856709X |
| Index Number: | Q523 |
| CLC: | Q523 |
| Call Number: | Q523/B329/2nd.ed. |
| Contents: |
2nd ed. Erratum slip inserted. Includes bibliographical references and index. DNA structure -- Watson-Crick model -- B-form DNA -- A-form DNA -- Z-form DNA -- Alternative DNA structures -- Cruciforms and Holliday junctions -- H-DNA -- Intrinsic curvature and DNA bending -- Intrinsic curvature -- DNA flexibility -- DNA supercoiling -- Historical perspective -- Closed-circular DNA and supercoiling -- Quantitative measure of DNA supercoiling -- Linking number -- Supercoiling, linking difference, and specific linking difference -- Geometric properties of closed-circular DNA -- Twist and writhe -- Interconversion of twist and writhe -- Nomenclature -- Topology and geometry of real DNA -- Agarose gel electrophoresis of plasmids -- Relaxation with topoisomerases -- Effect of intercalators -- Effect of protein binding -- Thermodynamics of DNA supercoiling -- Ethidium bromide titration -- Gaussian distribution of topoisomers -- Effect of DNA circle size -- Supercoiling in small DNA circles -- Biological effects of supercoiling free energy -- DNA on surfaces -- Helical repeat of DNA -- Surface linking treatment -- DNA winding number -- Surface linking number -- Interwound supercoiled DNA. (cont) Nucleosome -- Linking difference and the linking number paradox -- Early resolution of the linking number paradox -- Helical repeat at the nucleosome surface -- Measurements of hs for the nucleosome -- Topology and geometry of DNA in the nucleosome -- Knots and catenanes -- Knots -- Occcurrence of knots -- Description of knots -- Catenanes -- Occurrence of catenanes -- Description of catenanes -- Knots and catenanes as probes of DNA: protein interactions -- DNA topoisomerases -- Reactions of topoisomerases -- Mechanisms of topoisomerases -- Topoisomerases as drug targets -- Biological role of topoisomerases -- Biological consequences of DNA topology -- Introduction: the ubiquity of DNA supercoiling -- General biological consequences of negative supercoiling -- Genome organization -- Eukaryotes -- Prokaryotes -- Transcription: the twin supercoiled domain model -- New role for topoisomerases -- Control of gene expression -- RNA polymerase binding -- Transcriptional regulatory proteins -- Replication -- Replication initiation -- Replication elongation -- Termination of replication. |