Human immunodeficiency virus reverse transcriptase : a bench-to-bedside success /
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Group Author: | ; |
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Published: |
Springer,
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Publisher Address: | New York : |
Publication Dates: | [2013] |
Literature type: | Book |
Language: | English |
Subjects: | |
Carrier Form: | x, 361 pages : illustrations ; 24 cm |
Bibliography: | Includes bibliographical references and index. |
ISBN: |
9781461472902 (hardback : alkaline paper) : 1461472903 (hardback : alkaline paper) 1461472911 (electronic bk.) 9781461472919 (electronic bk.) |
Index Number: | QR201 |
CLC: | R512.91 |
Call Number: | R512.91/H918-8 |
Contents: |
Development of the First AIDS Drugs: AZT and Other Dideoxynueosides / Structure and Function of HIV RT. Proviral DNA Synthesis in HIV: Background / The RNase H Domain: Structure, Function and Mechanism / Conformational Dynamics of Reverse Transcription / Mechanism of Action of Approved RT Inhibitors. Nucleoside RT Inhibitors: Structural and Molecular Biology / Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) / Alternative Strategies to Interfere with the Function of HIV RT. Ribonuclease H Inhibitors: Structural and Molecular Biology / Targeting Small Molecules and Peptides to the p66-p51 Reverse Transcriptase Interface / Targeting RT Translocation / tRNA Primer Sequestration as an Antiviral Strategy / HIV Genetic Variability and the Problem of Drug Resistance. HIV Reverse Transcriptase Fidelity, Clade Diversity, and Acquisition of Drug Resistance / APOBECs and Their Role in Proviral DNA Synthesis / Role of RNase H Activity in NRTI/NNRTI Drug Resistance / HIV Population Dynamics / Prevention and Future Approaches. RT Inhibitors as Microbicides / |