Screen LibraryOptogenetics /
Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and...
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| Corporate Authors: | |
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| Group Author: | ; |
| Published: |
De Gruyter,
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| Publisher Address: | Berlin/Boston : |
| Publication Dates: | [2013] |
| Literature type: | eBook |
| Language: | English |
| Series: |
Dahlem workshop reports
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| Subjects: | |
| Online Access: |
http://dx.doi.org/10.1515/9783110270723 http://www.degruyter.com/doc/cover/9783110270723.jpg |
| Summary: |
Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and Restoration of vision and hearing. The concept and content was developed with top international researchers and students at a prestigious Dahlem Conference workshop. |
| Carrier Form: | 1 online resource(xiv,226 pages) : illustrations. |
| ISBN: | 9783110270723 |
| Index Number: | QP364 |
| CLC: | Q42 |
| Contents: |
Frontmatter -- Content -- Introduction -- 1 The biophysics and engineering of signaling photoreceptors / 2 Current challenges in optogenetics / 3 Challenges and opportunities for optochemical genetics / 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives / 5 Why optogenetic "control" is not (yet) control / 6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans / 7 Putting genetics into optogenetics: knocking out proteins with light / 8 Optogenetic approaches in behavioral neuroscience / 9 Combining genetic targeting and optical stimulation for circuit dissection in the zebrafish nervous system / 10 Optogenetic analysis of mammalian neural circuits / 11 Optogenetics to benefit human health: opportunities and challenges / 12 Optogenetic tools for controlling neural activity: molecules and hardware / 13 In vivo application of optogenetics in rodents / 14 Potential of optogenetics in deep brain stimulation / 15 Optogenetic approaches for vision restoration / 16 Restoration of vision the various approaches / 17 Optogenetic approaches to cochlear prosthetics for hearing restoration / 18 History in the making: the ethics of optogenetics / 19 Optogenetics as a new therapeutic tool in medicine? A view from the principles of biomedical ethics / Appendix -- Index. |