Screen LibrarySphingolipids : basic science and drug development /
Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipi...
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| Corporate Authors: | |
|---|---|
| Group Author: | ; |
| Published: |
Springer,
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| Publisher Address: | Vienna ; New York : |
| Publication Dates: | 2013. |
| Literature type: | eBook |
| Language: | English |
| Series: |
Handbook of experimental pharmacology,
v.215 |
| Subjects: | |
| Online Access: |
http://dx.doi.org/10.1007/978-3-7091-1368-4 |
| Summary: |
Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids' basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context. |
| Item Description: | Includes index. |
| Carrier Form: | 1 online resource. |
| ISBN: |
9783709113684 (electronic bk.) 3709113687 (electronic bk.) |
| Index Number: | QP752 |
| CLC: | Q54 |
| Contents: |
Basic Mechanisms. The Genetics of Sphingolipid Hydrolases and Sphingolipid Storage Diseases / Sphingolipids and Membrane Domains: Recent Advances / Sphingolipid Metabolism and Neutral Sphingomyelinases / Acid Sphingomyelinase / Ceramide Synthases: Reexamining Longevity / Membrane Channels Formed by Ceramide / Genetic Disorders of Simple Sphingolipid Metabolism / The Role of Ceramide-1-Phosphate in Biological Functions / Drug Development. Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) / Novel Drugs Targeting Sphingolipid Metabolism / The Therapeutic Potential of Nanoscale Sphingolipid Technologies / Novel Chemotherapeutic Drugs in Sphingolipid Cancer Research / Pharmacology of the Sphingosine-1-Phosphate Signalling System / |