Screen LibraryGood cascade impactor practices, AIM and EDA for orally inhaled products /
The purpose of this publication is to introduce a new, simpler and more effective way in which to interpret pharmaceutical aerosol particle size data from orally inhaled products (OIPs). Currently, the compendial and regulatory requirements dictate the need for measurements by full resolution multi-...
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| Corporate Authors: | |
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| Group Author: | ; ; |
| Published: |
Springer,
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| Publisher Address: | New York : |
| Publication Dates: | 2013. |
| Literature type: | eBook |
| Language: | English |
| Subjects: | |
| Online Access: |
http://dx.doi.org/10.1007/978-1-4614-6296-5 |
| Summary: |
The purpose of this publication is to introduce a new, simpler and more effective way in which to interpret pharmaceutical aerosol particle size data from orally inhaled products (OIPs). Currently, the compendial and regulatory requirements dictate the need for measurements by full resolution multi-stage cascade impactor (CI), a process that is demanding for the operator, time consuming, prone to experimental error, and challenging for method transfers from one laboratory to another. Furthermore, we shall show that the current practice of reducing information from mass-weighted aerodynamic par |
| Carrier Form: | 1 online resource |
| ISBN: |
9781461462965 (electronic bk.) 1461462967 (electronic bk.) |
| Index Number: | RS403 |
| CLC: | TQ46 |
| Contents: |
Introduction / Current Approaches to APSD Measurements of OIPs Based on Inertial Impaction / Physical Causes of APSD Changes in Aerosols from OIPs and Their Impact on CI Measurements / Good Cascade Impactor Practices / The AIM and EDA Concepts: Why They Are Needed and How They Fit Together / Product Life Cycle Approach to Cascade Impaction Measurements / Theoretical Basis for the EDA Concept / Performance Characterization of EDA and Its Potential to Improve Decision Making in Product Batch Release / Verification of the EDA Concept Through an Assessment of Theoretical Failure Modes, Failure Mode Analysis, and Case Studies with Real Data / Validating AIM-Based Instrumentation and Associated Measurement Techniques / The Regulatory and Compendial Pathways to Acceptance for AIM and EDA Concepts / Applying the AIM Concept in Support of Developing Improved In Vitro-In Vivo Relationships for OIPs / Future Directions for the AIM and EDA Concepts / Conclusions / |