Screen LibraryMitochondrial dysfunction /
Saved in:
| Corporate Authors: | |
|---|---|
| Group Author: | ; |
| Published: |
Academic Press,
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| Publisher Address: | San Diego : |
| Publication Dates: | 1993. |
| Literature type: | eBook |
| Language: | English |
| Series: |
Methods in toxicology,
v. 2 |
| Subjects: | |
| Online Access: |
http://www.sciencedirect.com/science/book/9780124612051 |
| Carrier Form: | 1 online resource (xx, 502 pages, [1] pages of plates) : illustrations. |
| Bibliography: | Includes bibliographical references and index. |
| Index Number: | QH603 |
| CLC: | Q731 |
| Contents: |
Introduction: criteria for assessing normal and abnormal mitochondrial function -- Systems for study of mitochondrial dysfunction -- Mitochondrial isolation from liver and kidney: strategy, techniques, and criteria for purity -- Mitochondrial isolation from brain: strategy, techniques, and criteria for purity -- Intact rat brain mitochondria from a single animal: preparation and properties -- Study of skeletal muscle mitochondrial dysfunction -- Small-scale preparation of skeletal muscle mitochondria and its application in the study of human disease -- Metabolic control analysis as a method to assess mitochondrial dysfunction -- Assessment of mitochondrial dysfunction in vivo and in organ systems -- Commentary: methods for in vivo assessment of mitochondrial function -- Noninvasive assessment of mitochondrial function by breath analysis using ketoisocaproic acid -- Absorption spectroscopy for assessment of mitochondrial function in vivo -- Analysis of mitochondrial function by carbon-13 nuclear magnetic resonance spectroscopy in intact tissues. (cont) Phosphorus-31 nuclear magnetic resonance spectroscopy in the study of mitochondrial metabolism -- Mitochondrial dysfunction in ischemic organs -- Screening for mitochondrial cytopathy: the subanaerobic threshold exercise test -- Assay of mitochondrial structural integrity -- Morphometry of mitochondria: size, internal structure, subcellular distribution, and three-dimensional reconstruction -- Megamitochondria -- Redox status and mitochondrial inner membrane permeability -- Mitochondrial metabolism and bioactivation and detoxification systems -- Assessment of mitochondrial glutathione as a measure of cell injury -- Experimental manipulation of mitochondrial glutathione concentrations -- Determination of flux, activity, and activity state of mitochondrial [alpha]-keto acid dehydrogenase complexes -- Regulation of oxygen uptake in the liver lobule by oxygen tension -- Generation of reactive oxygen metabolites and oxidative damage in mitochondria: role of calcium. (cont) Fatty acid metabolism and Reye's syndrome -- Antioxidative function of vitamin E and ubiquinols -- Mitochondrial NADPH -- Long-chain acyl-CoA metabolism by mitochondrial carnitine palmitoyltransferase: a cell model for pathological studies -- Mitochondrial energetics and transport processes -- Identification of mitochondrial dysfunction at coupling site I: loss of activity of NADH-ubiquinone oxidoreductase during myocardial ischemia -- Identification of mitochondrial dysfunction at coupling site II -- Cellular calcium and mitochondrial dysfunction -- Chronic alcoholism and the mitochondrial F F -ATP synthase -- Mitochondrial pyrophosphate metabolism in health and disease -- Toxic effects of calcium on mitochondria -- Calcium and the regulation of intramitochondrial dehydrogenases -- Use of fluorescent probes to monitor mitochondrial membrane potential in isolated mitochondria, cell suspensions, and cultured cells -- Genetic and developmental approaches to study of mitochondrial dysfunction -- Commentary: genetic approaches to mitochondrial DNA diseases of oxidative phosphorylation. (cont) Developmental aspects of mitochondrial dysfunction -- Mitochondrial DNA synthesis -- Covalent binding of reactive intermediates of xenobiotics to mitochondrial DNA -- Mitochondrial DNA repair and cell injury. |