Screen LibraryTelomerase inhibition：strategies and protocols
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| Group Author: | ; |
|---|---|
| Published: |
Humana Quantum [distributor],
|
| Publisher Address: | Totowa, N.J. Paisley |
| Publication Dates: | 2007. |
| Literature type: | Book |
| Language: | English |
| Series: |
Methods in molecular biology ; 405 |
| Subjects: | |
| Carrier Form: | x, 193 p.: ill. ; 24 cm. |
| ISBN: |
9781588296832 (hbk. : alk. paper) 1588296830 (hbk. : alk. paper) |
| Index Number: | R979 |
| CLC: |
R979.1 Q555 Q524 |
| Call Number: | Q555/T277 |
| Contents: |
Includes bibliographical references and index. Methods of telomerase inhibition -- Telomerase inhibition by synthetic nucleic acids and chemosensitization in human bladder cancer cell lines -- hTERT knockdown in human embryonic kidney cells using double-stranded RNA -- RNA interference using a plasmid construct expressing a short-hairpin RNA -- Retrovirus-mediated RNA interference -- Telomerase inhibition and telomere targeting in hematopoietic cancer cell lines with small non-nucleosidic synthetic compounds (BIBR1532) -- Uses of telomerase peptides in anti-tumor immune therapy -- Establishing cell-based reporter systems for the analysis of hTERT expression -- Telomerase RNA inhibition using antisense oligonucleotide against human telomerase RNA linked to a 2',5'-oligoadenylate -- Knockdown of telomerase RNA using hammerhead ribozymes and RNA interference -- Evaluation of tankyrase inhibition in whole cells -- Inhibition of telomerase by targeting MAP kinase signaling -- Screening of telomerase inhibitors -- Telomerase inhibition combined with other chemotherapeutic reagents to enhance anti-cancer effect. |