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Biology of IGF-1 its interaction with insulin in health and malignant states /

"The clinical use of long-term growth hormone treatment is increasing and such treatment leads to raised IGF-1 levels. Increased insulin levels are also more common as the prevalence of insulin resistance, which frequently presages obesity and/or type 2 diabetes, increases in the population. Th...

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Bibliographic Details
Corporate Authors: Symposium on Biology of IGF-1 Novartis Foundation
Group Author: Bock, Gregory; Goode, Jamie
Published:
Literature type: Electronic eBook
Language: English
Series: Novartis Foundation symposium ; 262
Subjects:
Somatomedin > Physiological effect > Congresses
Somatomedin > Pathophysiology > Congresses
Carcinogenesis > Congresses
Somatomédine > Effets physiologiques > Congrès
Somatomédine > Physiopathologie > Congrès
Cancérogenèse > Congrès
MEDICAL > Biochemistry
IGF
Interactie
Somatomedins > Congresses > physiology
Carcinogenicity Tests > Congresses
Risk assessment > Congresses
Chemical Biology and Biochemistry.
FACsci
ER > Internet > Book > Full text
Electronic books
Online Access: http://onlinelibrary.wiley.com/book/10.1002/0470869976
Summary: "The clinical use of long-term growth hormone treatment is increasing and such treatment leads to raised IGF-1 levels. Increased insulin levels are also more common as the prevalence of insulin resistance, which frequently presages obesity and/or type 2 diabetes, increases in the population. Therefore, a careful discussion of the role of IGF-1 and insulin in various cancers is urgently needed. This book examines these issues in detail. It features contributions from the leading scientists and clinicians in the field and should prove essential reading for anyone with a clinical interest in in
Carrier Form: 1 online resource (viii, 280 p.) : ill.
Bibliography: Includes bibliographical references and indexes.
ISBN: 0470869976 (electronic bk.)
9780470869970 (electronic bk.)
Index Number: QP552
CLC: R362-532
Contents: Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human

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